Programs and Committees
Alliance programs and committees function as a unified system where scientific ideas are generated, refined, and translated into clinical trials. Committees serve as the source of scientific concepts and collaborative review, while programs provide the methodological, operational, and scientific infrastructure needed to transform those concepts into rigorously designed studies.
The Alliance Network Operations Center (OPS Center) provides alignment across this system, integrating scientific leadership, operational oversight, and strategic direction. Working in close partnership with disease, modality, and administrative committees, as well as the Alliance’s scientific programs, it ensures that research ideas move efficiently from concept to clinical study.
Led by the Group Chair and Program Principal Investigator, the OPS Center supports:
- Disease committees
- Modality committees
- Administrative committees
The Alliance’s scientific programs provide the specialized expertise across distinct areas of cancer research and care—including clinical investigation, translational science, cancer control, and procedure-based oncology—that support the full life-cycle of clinical research—from concept development through study execution, analysis, and dissemination. Each program is led by a program director and principal investigator under the direction of the Group Chair and includes an operational unit and associated committees that work closely with disease committees to integrate program expertise into study development and execution.
The Statistics and Data Management Program provides the statistical design, data coordination, and analytical foundation that ensure rigor and reproducibility across all clinical trials.
The Central Protocol Operations Program supports protocol development, regulatory coordination, and trial implementation across the research network, and provides oversight for the Data Sharing Committee.
The Translational Research Program integrates molecular science, biomarkers, and biospecimen resources into clinical research, strengthening the connection between biological discovery and clinical application. It includes the Biorepository, Pathology and Laboratory Medicine, Pharmacogenomics and Population Pharmacology, and Translational Bioinformatics Committees.
The Cancer Control Program develops research focused on prevention, survivorship, health outcomes, access, and delivery of care across various populations. It includes the Cancer Care Delivery Research; Cancer in the Older Adult; Community Oncology, Populations, Education, Access, and Research (PEAR); Health Outcomes; Prevention; and Symptom Intervention Committees.
The Procedure-Based Therapy Program advances clinical research in surgery, radiation oncology, interventional oncology, and other procedure-based approaches to treat cancer. This program includes the Interventional Oncology Working Group and the Imaging, Radiation Oncology, and Surgery Committees.
This integrated structure ensures that scientific ideas are continuously developed, supported, and translated into clinical trials that are collaborative and focused on improving outcomes for patients with cancer.