High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Study Acronym: HOPE
Study Information
Alliance Study ID: A222301
NCT Study ID (ClinicalTrials.gov): NCT06992427
Alliance Committee: Cancer Control
Disease or Cancer Type: Head & Neck Cancers
Status: RECRUITING
Study Description
This phase III trial tests if gabapentin can prevent the need for opiate pain medication for mouth sores (oral mucositis) in patients undergoing treatment with chemotherapy and radiation for squamous cell carcinoma of the head and neck region. Oral mucositis is a common side effect of radiation treatment and can cause severe pain, dysphagia, and weight loss resulting in feeding tube placement, worse health-related quality of life, treatment interruptions, unplanned hospitalizations, and significant financial burden. Mucositis pain is often treated with opioid pain medications which do provide pain relief but have many known side effects not limited to mental clouding, constipation, fatigue, endocrinopathy, neurotoxicity, sleep-disordered breathing, and most distressingly persistent opioid use. Gabapentin may help relieve pain from oral mucositis caused by radiation while also reducing the need for opiate pain medications for patients receiving chemotherapy and radiation for squamous cell carcinoma of the head and neck region
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Locations (200)
Arizona Center for Cancer Care – Gilbert
Gilbert, Arizona 85297
United States
Arizona Center for Cancer Care-Peoria
Peoria, Arizona 85381
United States
Arizona Center for Cancer Care – Biltmore
Phoenix, Arizona 85016
United States
Arizona Center for Cancer Care – Phoenix
Phoenix, Arizona 85027
United States
Arizona Center for Cancer Care – Osborn
Scottsdale, Arizona 85251
United States
Arizona Center for Cancer Care – Scottsdale
Scottsdale, Arizona 85258
United States
Arizona Center for Cancer Care-Surprise
Surprise, Arizona 85374
United States
Arizona Center for Cancer Care
Tempe, Arizona 85284
United States
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California 93301
United States
Kaiser Permanente Dublin
Dublin, California 94568
United States
Kaiser Permanente-Fremont
Fremont, California 94538
United States
Kaiser Permanente Fresno Orchard Plaza
Fresno, California 93720
United States
Los Angeles General Medical Center
Los Angeles, California 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Kaiser Permanente- Modesto MOB II
Modesto, California 95356
United States
Kaiser Permanente-Modesto
Modesto, California 95356
United States
Kaiser Permanente-Oakland
Oakland, California 94611
United States
Kaiser Permanente-Roseville
Roseville, California 95661
United States
Kaiser Permanente Downtown Commons
Sacramento, California 95814
United States
Kaiser Permanente-South Sacramento
Sacramento, California 95823
United States
Kaiser Permanente-San Francisco
San Francisco, California 94115
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
United States
Kaiser Permanente San Leandro
San Leandro, California 94577
United States
Kaiser San Rafael-Gallinas
San Rafael, California 94903
United States
Kaiser Permanente Medical Center – Santa Clara
Santa Clara, California 95051
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
United States
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
United States
Kaiser Permanente-Vallejo
Vallejo, California 94589
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Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
United States
Kaiser Permanente-Franklin
Denver, Colorado 80205
United States
Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
United States
Saint Anthony Hospital
Lakewood, Colorado 80228
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Rush-Copley Medical Center
Aurora, Illinois 60504
United States
Advocate Outpatient Center – Aurora
Aurora, Illinois 60506
United States
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
AMG Crystal Lake – Oncology
Crystal Lake, Illinois 60014
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Advocate Sherman Hospital
Elgin, Illinois 60123
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
AMG Libertyville – Oncology
Libertyville, Illinois 60048
United States
Condell Memorial Hospital
Libertyville, Illinois 60048
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Trinity Medical Center
Moline, Illinois 61265
United States
Carle BroMenn Medical Center
Normal, Illinois 61761
United States
Carle Cancer Institute Normal
Normal, Illinois 61761
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
HSHS Saint Elizabeth’s Hospital
O’Fallon, Illinois 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
United States
Advocate Outpatient Center – Oak Lawn
Oak Lawn, Illinois 60453
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Advocate High Tech Medical Park
Palos Heights, Illinois 60463
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
Saint Luke’s Hospital
Cedar Rapids, Iowa 52402
United States
Mercy Hospital
Cedar Rapids, Iowa 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
United States
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa 51503
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
Harold Alfond Center for Cancer Care
Augusta, Maine 04330
United States
MaineHealth Coastal Cancer Treatment Center
Bath, Maine 04530
United States
MaineHealth Cancer Care and IV Therapy – Brunswick
Brunswick, Maine 04011
United States
MaineHealth LincolnHealth Hospital
Damariscotta, Maine 04543
United States
MaineHealth Maine Medical Center – Portland
Portland, Maine 04102
United States
MaineHealth Cancer Care Center of York County
Sanford, Maine 04073
United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine 04074
United States
MaineHealth Cancer Care and IV Therapy – South Portland
South Portland, Maine 04106
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Freeman Health System
Joplin, Missouri 64804
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska 68123
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CHI Health Good Samaritan
Kearney, Nebraska 68847
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Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
Jefferson Cherry Hill Hospital
Cherry Hill, New Jersey 08002
United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey 08080
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills, New York 11375
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
Manhattan Eye Ear and Throat Hospital
New York, New York 10065
United States
Lenox Hill Hospital
New York, New York 10075
United States
Queens Cancer Center
Rego Park, New York 11374
United States
Stony Brook University Medical Center
Stony Brook, New York 11794
United States
Montefiore Medical Center-Einstein Campus
The Bronx, New York 10461
United States
Montefiore Medical Center – Moses Campus
The Bronx, New York 10467
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Aultman Health Foundation
Canton, Ohio 44710
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Geisinger Medical Center
Danville, Pennsylvania 17822
United States
Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania 18519
United States
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
United States
Saint Vincent Hospital
Erie, Pennsylvania 16544
United States
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania 16121
United States
UPMC Cancer Centers – Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
United States
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
United States
Forbes Hospital
Monroeville, Pennsylvania 15146
United States
UPMC Cancer Center – Monroeville
Monroeville, Pennsylvania 15146
United States
UPMC Hillman Cancer Center – Monroeville
Monroeville, Pennsylvania 15146
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania 19114
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania 15232
United States
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania 15243
United States
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania 17901
United States
UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania 16346
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
United States
Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Farmington Health Center
Farmington, Utah 84025
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
South Jordan Health Center
South Jordan, Utah 84009
United States
United Hospital Center
Bridgeport, West Virginia 26330
United States
WVUH-Berkely Medical Center
Martinsburg, West Virginia 25401
United States
West Virginia University Healthcare
Morgantown, West Virginia 26506
United States
Camden Clark Medical Center
Parkersburg, West Virginia 26101
United States
Princeton Community Hospital
Princeton, West Virginia 24740
United States
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia 26003
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Aurora Saint Luke’s South Shore
Cudahy, Wisconsin 53110
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Aspirus Medford Hospital
Medford, Wisconsin 54451
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Aspirus Cancer Care – James Beck Cancer Center
Rhinelander, Wisconsin 54501
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Aspirus Cancer Care – Stevens Point
Stevens Point, Wisconsin 54481
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
Aspirus Cancer Care – Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
United States
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