Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
Study Acronym: POSITIVE
Study Information
Alliance Study ID: Alliance A221405
NCT Study ID (ClinicalTrials.gov): NCT02308085
Alliance Committee: Cancer Control
Disease or Cancer Type: Breast Cancer
Alliance Study Chair: Olivia Pagani, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
The best available evidence suggests that pregnancy after breast cancer does not increase a woman’s risk of developing a recurrence from her breast cancer. In particular, the most recent data suggest that this is the case also in women with a hormone receptor-positive breast cancer. There is also no indication of increased risk for delivery complications or for the newborn. The aim of the study is to investigate if temporary interruption of endocrine therapy, with the goal to permit pregnancy, is associated with a higher risk of breast cancer recurrence.The study aims also to evaluate different specific indicators related to fertility, pregnancy and breast cancer biology in young women. A psycho-oncological companion study on fertility concerns, psychological well-being and decisional conflicts will be conducted in interested Centers.
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
Locations (211)
Cedars Sinai Medical Centre
Los Angeles, California 90211
United States
Stanford Cancer Institute
Palo Alto, California 94305
United States
Sharp Memorial Hospital
San Diego, California
United States
University of Colorado Cancer Centre – Anschutz Cancer Pavilion
Aurora, Colorado 80045
United States
Rocky Mountain Cancer Center
Boulder, Colorado 80303
United States
SCL Health Saint Joseph Hospital
Denver, Colorado 80218
United States
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States
Yale University – Yale Cancer Centre
New Haven, Connecticut 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
United States
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
United States
Helen F. Graham Cancer Center
Newark, Delaware 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
United States
Medical Oncology Hematology Consultants PA
Newport, Delaware 19713
United States
Regional Hematology Oncology Practice Associates
Newport, Delaware 19713
United States
Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
Sibley Memorial Hospital
Washington D.C., District of Columbia 20016
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Emory University
Atlanta, Georgia 30322
United States
Straub Clinic and Hospital
Honolulu, Hawaii 96701
United States
OnCare Hawaii Inc – POB I
Honolulu, Hawaii 96813
United States
Queen’s Medical Centre
Honolulu, Hawaii 96813
United States
OnCare Hawaii-Kuakini
Honolulu, Hawaii 96817
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
United States
Carle on Vermilion
Danville, Illinois 61832
United States
Carle Physician Group – Effingham
Effingham, Illinois 62401
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States
Northwestern University
Evanston, Illinois 60201
United States
NorthShore University Health System – Glenbrook Hospital
Glenview, Illinois 60026
United States
NorthShore Unversity Health System – Highland Park Hospital
Highland Park, Illinois 60035
United States
Mattoon Charleston Primary Care
Mattoon, Illinois 61938
United States
NorthShore Medical Centre
Skokie, Illinois 60076
United States
Carle Cancer Centre
Urbana, Illinois 61801
United States
The Carle Foundation Hospital
Urbana, Illinois 61801
United States
Indiana University
Indianapolis, Indiana 46202
United States
Greater Baltimore Medical Centre
Baltimore, Maryland 21204
United States
Johns Hopkins University
Baltimore, Maryland 21218
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215-5450
United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48103
United States
IHA Hematology Consultants-Brighton
Brighton, Michigan 48114
United States
Saint Joseph Mercy Hospital – Brighton
Brighton, Michigan 48114
United States
IHA Hematology Consultants-Canton
Canton, Michigan 48188
United States
Saint Joseph Mercy Hospital- Canton
Canton, Michigan 48188
United States
IHA Hematology Consultants-Chelsea
Chelsea, Michigan 48118
United States
Saint Joseph Mercy Hospital – Chelsea
Chelsea, Michigan 48118
United States
IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan 48198
United States
Sanford Clinic North – Bemidji
Bemidji, Minnesota 56501
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Essentia Health Cancer Center
Duluth, Minnesota 55805-1951
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
St John’s Hospital
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital, 800 East 28th Street
Minneapolis, Minnesota 55407
United States
Hennepin County Medical Center – Cancer Center
Minneapolis, Minnesota 55415
United States
Mayo Clinic
Rochester, Minnesota 55902
United States
Park Nicollet Methodist Hospital
Saint Louis Park, Minnesota 55343
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Bozeman Deaconess Hospital
Bozeman, Montana 59715
United States
Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center
Lebanon, New Hampshire 03756
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico 87131
United States
Weill Medical College of Cornell University
New York, New York 10065
United States
SUNY Upstate Medical University
Syracuse, New York 13210
United States
Montefiore Medical Center – Einstein Campus, 1695 Eastchester Road
The Bronx, New York 10461
United States
Montefiore Medical Center-Weiler Hospital
The Bronx, New York 10461
United States
Montefiore Medical Center – Moses Campus, 111 East 210th Street
The Bronx, New York 10467
United States
Dickstein Cancer Treatment Centre
White Plains, New York 10601
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Southeastern Medical Oncology Centre
Clinton, North Carolina 28328
United States
Southeastern Medical Oncology Centre
Goldsboro, North Carolina 27534
United States
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina
United States
Southeastern Medical Oncology Centre
Jacksonville, North Carolina 28546
United States
Southeastern Medical Oncology Centre
Wilson, North Carolina 27534
United States
Sanford Bismark Medical Centre
Bismarck, North Dakota 58501
United States
Sanford Roger Maris Cancer Centre
Fargo, North Dakota 58102
United States
Sanford Medical Centre
Fargo, North Dakota 58122
United States
Case Western Reserve University
Cleveland, Ohio 44106
United States
Ohio State University
Columbus, Ohio 43210
United States
Chagrin Highlands
Orange, Ohio 44122
United States
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania 15213
United States
Women and Infants Hospital of Rhode Island
Providence, Rhode Island 02905
United States
Greenville Health System Cancer Institute-Butternut
Greenville, South Carolina 29605
United States
Greenville Health System Cancer Institute-Faris
Greenville, South Carolina 29605
United States
Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina 29611
United States
Greenville Health System Cancer Institute-Greer
Greer, South Carolina 29650
United States
Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina 29672
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina 29307
United States
Sanford Cancer Centre Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Centre – Sioux Falls
Sioux Falls, South Dakota 57104
United States
Doctor’s Hospital of Laredo
Laredo, Texas 78045
United States
Huntsman Cancer Institute / University of Utah
Salt Lake City, Utah 84112
United States
University of Vermont Medical Centre
Burlington, Vermont 05401
United States
Bon Secours Memorial Regional Medical Centre
Mechanicsville, Virginia 23116
United States
Bon Secours Saint Francis Medical Centre
Midlothian, Virginia 23114
United States
Bon Secours Saint Mary’s Hospital
Richmond, Virginia 23223
United States
Fred Hutchinson Cancer Research Center
Seattle, Washington 98109
United States
Seattle Cancer Care Alliance
Seattle, Washington 98109
United States
University of Washington Medical Center
Seattle, Washington 98195
United States
St John of God Subiaco Hospital
Perth, Western Australia 6008
Australia
Univ. Klinik f. Frauenheilkunde u. Geburtshilfe
Graz, 8036
Austria
Univ. Klinik f. Frauenheilkunde Innsbruck
Innsbruck, 6020
Austria
LKH Salzburg
Salzburg, 5020
Austria
Med. Univ. Klinik f. Chir
Vienna, 1090
Austria
Cliniques Universitaires Saint-Luc
Brussels, 1200
Belgium
Cliniques Universitaires Saint-Luc Brussels
Brussels
Belgium
Institut Jules Bordet
Brussels
Belgium
UZ Leuven
Leuven, 3000
Belgium
C.H.U. Sart-Tilman
Liège, 4000
Belgium
Clinique St.Elizabeth
Namur, 5000
Belgium
Tom Baker Cancer Centre
Calgary, Alberta T2N 4N2
Canada
Vancouver Cancer Centre
Vancouver, British Columbia V5Z 1M9
Canada
St Michael’s Hospital
Toronto, Ontario M5B 1W8
Canada
Mount Sinai Hospital
Toronto, Ontario M5G 1X5
Canada
Odette Cancer Centre – Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada
CHUM – Centre Hospitalier de l’Universite de Montreal
Montreal, Quebec H2X 3E4
Canada
CHA-Hopital Du St-Sacrement
Québec, Quebec G1S 4L8
Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec
Canada
Rigshospitalet
Copenhagen, 2100
Denmark
Institut Bergonie
Bordeaux, 33076
France
Centre Oscar Lambret
Lille, 59020
France
French Lyon Cancer Center
Lyon, 69373
France
APHP, Tenon Hospital in Paris
Paris
France
University General Hospital of Heraklion
Stavrakia, Crete 71110
Greece
Laso General Hospital, First Department of Medical Oncology
Athens
Greece
Debrecen University Dep. of Oncology
Debrecen
Hungary
St Vincent’s University Hospital
Dublin
Ireland
St. James’s Hospital
Dublin
Ireland
Galway University Hospital
Galway
Ireland
University Hospital Limerick
Limerick
Ireland
University Hospital Waterford
Waterford
Ireland
Shaare Zedek Medical Center
Jerusalem
Israel
Chaim Sheba Medical Center
Tel Litwinsky, 5265601
Israel
Ospedale di Prato
Prato, Firenze
Italy
U.O Medicina Oncologica Ospedale di Carpi
Carpi, Modena 41012
Italy
Ospedale di Trento
Trento, Trento 38122
Italy
Multimedica Spa
Castellanza, Vareze
Italy
Centro di Riferimento Oncologico
Aviano, 33081
Italy
Ospedale degli Infermi – S. C. Oncologia Medica
Biella
Italy
Azienda Sanitaria di Bolzano
Bolzano, 39100
Italy
Istituto Nazionale Ricerca Cancro
Genova
Italy
Istituto scientifico Romagnolo per lo studio e la cura
Meldola
Italy
Istituto Europeo di Oncologia (IEO)
Milan, 20141
Italy
University of Eastern Piedmont
Novara, 28100
Italy
Salvatore Maugeri Foundation – Medical Oncology Unit
Pavia, 27100
Italy
UO Oncologia, Rimini Hospital
Rimini, 47923
Italy
Regina Elena National Cancer Institute
Rome
Italy
AO Universitaria Ospedale Di Circolo e Fondazione
Varese, 21100
Italy
Ospedale Belcolle di Viterbo
Viterbo
Italy
Kansai Rosai Hospital
Amagasaki, Hyōgo 660-8511
Japan
Seirei Hamamatsu General Hospital
Hamamatsu, Shizuoka
Japan
NHO Kyushu Cancer Centre, 3-1-1 Notame Minami-ku Fukuoka-shi
Fukuoka, 811-1395
Japan
Social Medical Corporation Hakuaikai Sagara Hospital
Kagoshima
Japan
St Marianna University School of Medicine Hospital
Kawasaki
Japan
Kyoto University Hospital
Kyoto
Japan
NHO Shikoku Cancer Center
Matsuyama
Japan
Toranomon Hospital
Minato-ku, Tokyo, 105-8470
Japan
Kamiiida Daiichi General Hospital
Nagoya, 463-0802
Japan
Okayama University Hospital
Okayama
Japan
NHO Osaka National Hospital
Ōsaka
Japan
Tohoku University Hospital
Sendai
Japan
National Cancer Center for Global Medicine
Tokyo
Japan
National Cancer Center Hospital
Tokyo
Japan
Showa University Hospital
Tokyo
Japan
St Luke’s International Hospital
Tokyo
Japan
The Cancer Institute Hospital of JFCR
Tokyo
Japan
University of Tsukuba
Tsukuba
Japan
American University of Beirut Medical Center
Beirut
Lebanon
Leiden University Medical Centre, Albinusdreef 2, Postbus 9600
Leiden, 2300 RC
Netherlands
Norwegian Radium Hospital (Oslo University)
Oslo
Norway
Champalimaud Cancer Center – Breast Cancer Unit
Lisbon
Portugal
Institute of Oncology & Radiology of Serbia
Belgrade
Serbia
Institute of Oncology Ljubljana – Medical Oncology Department
Ljubljana
Slovenia
Samsung Medical Center
Seoul, 06351
South Korea
Asan Medical Center
Seoul
South Korea
Seoul National University Hospital
Seoul
South Korea
Hospital Clinico Universitario Virgen de la Arrixaca
El Palmar, Murcia
Spain
Hospital Universitario Vall d’Hebron
Barcelona, 08035
Spain
Hospital General de Catalunya
Barcelona
Spain
Hospital Universitario Donostia
Donostia / San Sebastian
Spain
Instituto Catalán de Oncología de Gerona Hospital
Girona
Spain
Hospital Universitario HM Sanchinarro – Centro Integral Oncologico Clara Campal (CIOCC)
Madrid, 28050
Spain
Hospital Clinico San Carlos
Madrid
Spain
Hospital Universitario de Fuenlabrada
Madrid
Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, 29010
Spain
Hospital Universitario Central de Asturias
Oviedo
Spain
Hospital Son Espases, Palma de Mallorca
Palma
Spain
Complejo Hospitalario de Navarra
Pamplona
Spain
Complejo Hospitalario Universitario de Santiago
Santiago de Compostela
Spain
Universitario Virgen del Rocio
Seville, 41013
Spain
Hospital Quiron Sagrado Corazon
Seville
Spain
Hospital Virgen De La Salud
Toledo
Spain
Hospital General Universitario de Valencia – Servico Oncologia
Valencia
Spain
Hospital Clinico Universitario Lozano Blesa
Zaragoza
Spain
Inselspital Bern
Bern, Canton of Bern 3010
Switzerland
Spital STS AG Onkologiezentrum Thun-Berner Oberland
Thun, Canton of Bern 3600
Switzerland
Kantonspital Baden AG
Baden, 5404
Switzerland
Universitätsspital Basel
Basel, 4031
Switzerland
Istituto Oncologico della Svizzera Italiana (IOSI)
Bellinzona
Switzerland
Oncocare Bern
Bern, 3012
Switzerland
Brustzentrum Thurgau – Obstetrics and Gynecology
Frauenfeld
Switzerland
University Hospital Geneva
Geneva, 1211
Switzerland
University Hospital of Lausanne (CHUV) BH06 – Oncology Department
Lausanne
Switzerland
Brustzentum Kantonsspital St. Gallen
Sankt Gallen, 9007
Switzerland
CHCVs Hôpital de Sion – Service d’oncologie ambulatoire
Sion, 736
Switzerland
Brust-Zentrum AG
Zurich, 8008
Switzerland
University Hospital Zurich
Zurich, 8091
Switzerland
Data Sources & Contacts
Full trial details
For more Information