Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
Study Information
Alliance Study ID: N08CB
NCT Study ID (ClinicalTrials.gov): NCT01099449
Alliance Committee: Cancer Control
Disease or Cancer Type: Colorectal / Colon / Rectal Cancer
Alliance Study Chair: Charles L. Loprinzi, MD
Status: COMPLETED
Study Description
RATIONALE: Chemoprotective drugs, such as calcium gluconate and magnesium sulfate, may prevent neurotoxicity caused by oxaliplatin. It is not yet known which administration schedule of calcium gluconate and magnesium sulfate is more effective in preventing neurotoxicity.
PURPOSE: This randomized phase III trial is studying different administration schedules of calcium gluconate and magnesium sulfate and comparing how well they work in neurotoxicity in patients with colon cancer or rectal cancer receiving oxaliplatin-based combination chemotherapy.
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