Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
Study Information
Alliance Study ID: A091903
NCT Study ID (ClinicalTrials.gov): NCT05111574
Alliance Committee: Experimental Therapeutics
Disease or Cancer Type: Melanoma & Skin Cancers
Alliance Study Chair: Alexander N Shoushtari
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II trial tests whether nivolumab in combination with cabozantinib works in patients with mucosal melanoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It works by blocking the action of an abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving nivolumab in combination with cabozantinib could prevent cancer from returning.
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Locations (147)
Sutter Auburn Faith Hospital
Auburn, California 95602
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
United States
Palo Alto Medical Foundation-Fremont
Fremont, California 94538
United States
Keck Medicine of USC Koreatown
Los Angeles, California 90020
United States
Los Angeles General Medical Center
Los Angeles, California 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Memorial Medical Center
Modesto, California 95355
United States
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California 92663
United States
Palo Alto Medical Foundation Health Care
Palo Alto, California 94301
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
United States
Sutter Roseville Medical Center
Roseville, California 95661
United States
Sutter Medical Center Sacramento
Sacramento, California 95816
United States
California Pacific Medical Center-Pacific Campus
San Francisco, California 94115
United States
UCSF Medical Center-Mission Bay
San Francisco, California 94158
United States
Mills Health Center
San Mateo, California 94401
United States
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California 95065
United States
Sutter Pacific Medical Foundation
Santa Rosa, California 95403
United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California 94086
United States
Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
United States
The Melanoma and Skin Cancer Institute
Englewood, Colorado 80113
United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Rush-Copley Medical Center
Aurora, Illinois 60504
United States
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Northwestern University
Chicago, Illinois 60611
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
UI Health Care Mission Cancer and Blood – West Des Moines Clinic
Clive, Iowa 50325
United States
Mercy Medical Center – Des Moines
Des Moines, Iowa 50314
United States
UI Health Care Mission Cancer and Blood – Laurel Clinic
Des Moines, Iowa 50314
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Bronson Battle Creek
Battle Creek, Michigan 49017
United States
Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
United States
Corewell Health Lakeland Hospitals – Niles Hospital
Niles, Michigan 49120
United States
Cancer and Hematology Centers of Western Michigan – Norton Shores
Norton Shores, Michigan 49444
United States
Corewell Health Reed City Hospital
Reed City, Michigan 49677
United States
Corewell Health Lakeland Hospitals – Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States
Munson Medical Center
Traverse City, Michigan 49684
United States
University of Michigan Health – West
Wyoming, Michigan 49519
United States
Minnesota Oncology – Burnsville
Burnsville, Minnesota 55337
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Hematology Oncology Associates of CNY at Camillus
Camillus, New York 13031
United States
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York 13057
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
NYU Langone Hospital – Long Island
Mineola, New York 11501
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Good Samaritan Hospital – Cincinnati
Cincinnati, Ohio 45220
United States
Case Western Reserve University
Cleveland, Ohio 44106
United States
MetroHealth Medical Center
Cleveland, Ohio 44109
United States
Miami Valley Hospital
Dayton, Ohio 45409
United States
Premier Blood and Cancer Center
Dayton, Ohio 45409
United States
Dayton Physician LLC – Englewood
Dayton, Ohio 45415
United States
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
United States
Kettering Medical Center
Kettering, Ohio 45429
United States
Upper Valley Medical Center
Troy, Ohio 45373
United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
United States
Rapid City Regional Hospital
Rapid City, South Dakota 57701
United States
Avera Cancer Institute
Sioux Falls, South Dakota 57105
United States
UT MD Anderson Cancer Center
Houston, Texas 77030
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
HSHS Sacred Heart Hospital
Eau Claire, Wisconsin 54701
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary’s
Green Bay, Wisconsin 54303
United States
University of Wisconsin Carbone Cancer Center – Eastpark Medical Center
Madison, Wisconsin 53718
United States
University of Wisconsin Carbone Cancer Center – University Hospital
Madison, Wisconsin 53792
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario K1H 8L6
Canada
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario M4N 3M5
Canada
University Health Network-Princess Margaret Hospital
Toronto, Ontario M5G 2M9
Canada
Jewish General Hospital
Montreal, Quebec H3T 1E2
Canada
Data Sources & Contacts
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