Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer
Study Information
Alliance Study ID: A022004
NCT Study ID (ClinicalTrials.gov): NCT05710406
Alliance Committee: Gastrointestinal Cancer
Disease or Cancer Type: Colorectal / Colon / Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II/III trial compares the effect of the combination of encorafenib and cetuximab to usual care (patient observation) for reducing the chance of cancer recurrence after standard surgery and chemotherapy in patients with BRAF-mutated stage IIB-III colon cancer. Encorafenib is in a class of medications called kinase inhibitors. It is used in patients whose cancer has a certain mutation (change) in the BRAF gene. It works by blocking the action of mutated BRAF that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of tumor cells. This may help keep tumor cells from growing. Giving encorafenib and cetuximab combination after standard surgery and chemotherapy may be more effective at reducing the chance of cancer recurrence compared to the usual patient observation.
Related Publications
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Locations (202)
Beebe South Coastal Health Campus
Millville, Delaware 19967
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United States
Emory Saint Joseph’s Hospital
Atlanta, Georgia 30342
United States
Emory Johns Creek Hospital
Johns Creek, Georgia 30097
United States
Hawaii Cancer Care Inc – Waterfront Plaza
Honolulu, Hawaii 96813
United States
Queen’s Cancer Cenrer – POB I
Honolulu, Hawaii 96813
United States
Queen’s Medical Center
Honolulu, Hawaii 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii 96813
United States
Queen’s Cancer Center – Kuakini
Honolulu, Hawaii 96817
United States
Hawaii Cancer Care – Westridge
‘Aiea, Hawaii 96701
United States
Pali Momi Medical Center
‘Aiea, Hawaii 96701
United States
The Queen’s Medical Center – West Oahu
‘Ewa Beach, Hawaii 96706
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Saint Luke’s Cancer Institute – Twin Falls
Twin Falls, Idaho 83301
United States
Rush – Copley Medical Center
Aurora, Illinois 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Northwest Cancer Center – Main Campus
Crown Point, Indiana 46307
United States
Northwest Oncology LLC
Dyer, Indiana 46311
United States
Northwest Cancer Center – Hobart
Hobart, Indiana 46342
United States
Saint Mary Medical Center
Hobart, Indiana 46342
United States
Saint Catherine Hospital
Indianapolis, Indiana 46312
United States
The Community Hospital
Munster, Indiana 46321
United States
Women’s Diagnostic Center – Munster
Munster, Indiana 46321
United States
Northwest Cancer Center – Valparaiso
Valparaiso, Indiana 46383
United States
Mission Cancer and Blood – Ankeny
Ankeny, Iowa 50023
United States
Mercy Hospital
Cedar Rapids, Iowa 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
United States
Mission Cancer and Blood – Des Moines
Des Moines, Iowa 50309
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
East White Plains, New York 10604
United States
Glens Falls Hospital
Glens Falls, New York 12801
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Upstate Cancer Center at Oswego
Oswego, New York 13126
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
SUNY Upstate Medical Center-Community Campus
Syracuse, New York 13215
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Upstate Cancer Center at Verona
Verona, New York 13478
United States
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
United States
CaroMont Regional Medical Center
Gastonia, North Carolina 28054
United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Aultman Health Foundation
Canton, Ohio 44710
United States
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Miami Valley Hospital
Dayton, Ohio 45409
United States
Premier Blood and Cancer Center
Dayton, Ohio 45409
United States
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
United States
Cleveland Clinic Cancer Center Independence
Independence, Ohio 44131
United States
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
United States
North Coast Cancer Care
Sandusky, Ohio 44870
United States
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
United States
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
United States
Upper Valley Medical Center
Troy, Ohio 45373
United States
South Pointe Hospital
Warrensville Heights, Ohio 44122
United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
United States
Lehigh Valley Hospital – Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Geisinger Medical Center
Danville, Pennsylvania 17822
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania 18201
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
United States
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania 17901
United States
Community Medical Center
Scranton, Pennsylvania 18510
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States
Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
United States
Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
United States
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina 29341
United States
Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
MGC Hematology Oncology-Union
Union, South Carolina 29379
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Parkland Memorial Hospital
Dallas, Texas 75235
United States
UT Southwestern Simmons Cancer Center – RedBird
Dallas, Texas 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
United States
University of Virginia Cancer Center
Charlottesville, Virginia 22908
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
United States
ThedaCare Cancer Care – Berlin
Berlin, Wisconsin 54923
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Aspirus Medford Hospital
Medford, Wisconsin 54451
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
ThedaCare Regional Medical Center – Neenah
Neenah, Wisconsin 54956
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Aspirus Cancer Care – James Beck Cancer Center
Rhinelander, Wisconsin 54501
United States
ThedaCare Cancer Care – Shawano
Shawano, Wisconsin 54166
United States
Aspirus Cancer Care – Stevens Point
Stevens Point, Wisconsin 54481
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
ThedaCare Cancer Care – Waupaca
Waupaca, Wisconsin 54981
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Aspirus Cancer Care – Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
United States
Data Sources & Contacts
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