Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma
Study Information
Alliance Study ID: A062101
NCT Study ID (ClinicalTrials.gov): NCT06232044
Alliance Committee: Myeloma
Disease or Cancer Type: Multiple Myeloma & Plasma Cell Disorders
Alliance Study Chair: Clifton Mo
Status: RECRUITING
Study Description
This phase I/II trial tests the safety, side effects, best dose, and effectiveness of iberdomide in combination with belantamab mafodotin and dexamethasone in treating patients with multiple myeloma (MM) that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). Multiple myeloma is a cancer that affects white blood cells called plasma cells, which are made in the bone marrow and are part of the immune system. Multiple myeloma cells have a protein on their surface called B-cell maturation antigen (BCMA) that allows the cancer cells to survive and grow. Immunotherapy with iberdomide, may induce changes in body’s immune system and may interfere with the ability of cancer cells to grow and spread. Belantamab mafodotin has been designed to attach to the BCMA protein, which may cause the myeloma cell to become damaged and die. Dexamethasone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body’s immune response to help lessen the side effects of chemotherapy drugs. Iberdomide plus belantamab mafodotin may help slow or stop the growth of cancer in patients with multiple myeloma.
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Locations (42)
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
Tufts Medical Center
Boston, Massachusetts 02111
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
OhioHealth O’Bleness Hospital
Athens, Ohio 45701
United States
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
United States
Riverside Methodist Hospital
Columbus, Ohio 43214
United States
Grant Medical Center
Columbus, Ohio 43215
United States
Doctors Hospital
Columbus, Ohio 43228
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
United States
Grady Memorial Hospital
Delaware, Ohio 43015
United States
Columbus Oncology and Hematology Associates
Dublin, Ohio 43016
United States
Dublin Methodist Hospital
Dublin, Ohio 43016
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
United States
OhioHealth Marion General Hospital
Marion, Ohio 43302
United States
OhioHealth Pickerington Methodist Hospital
Pickerington, Ohio 43147
United States
OhioHealth Westerville Medical Campus/Westerville Cancer Center
Westerville, Ohio 43082
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary’s
Green Bay, Wisconsin 54303
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
United States
Sheboygan Physicians Group
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Data Sources & Contacts
Full trial details
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