Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study
Study Information
Alliance Study ID: A032001
NCT Study ID (ClinicalTrials.gov): NCT05092958
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Genitourinary Cancers – Kidney / Bladder / Urothelial / Testicular
Alliance Study Chair: Shilpa Gupta
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib and avelumab together may further shrink the cancer or prevent it from returning/progressing.
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Locations (275)
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
Sutter Auburn Faith Hospital
Auburn, California 95602
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
United States
Palo Alto Medical Foundation-Fremont
Fremont, California 94538
United States
Memorial Medical Center
Modesto, California 95355
United States
Palo Alto Medical Foundation-Camino Division
Mountain View, California 94040
United States
Palo Alto Medical Foundation Health Care
Palo Alto, California 94301
United States
Sutter Roseville Medical Center
Roseville, California 95661
United States
Sutter Medical Center Sacramento
Sacramento, California 95816
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
California Pacific Medical Center-Pacific Campus
San Francisco, California 94115
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Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California 95065
United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California 94086
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Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
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Beebe South Coastal Health Campus
Millville, Delaware 19967
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia 20010
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
Cleveland Clinic-Weston
Weston, Florida 33331
United States
Rush-Copley Medical Center
Aurora, Illinois 60504
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Advocate Good Shepherd Hospital
Barrington, Illinois 60010
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Northwestern University
Chicago, Illinois 60611
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Rush MD Anderson Cancer Center
Chicago, Illinois 60612
United States
University of Illinois
Chicago, Illinois 60612
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
AMG Crystal Lake – Oncology
Crystal Lake, Illinois 60014
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Advocate Sherman Hospital
Elgin, Illinois 60123
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
AMG Libertyville – Oncology
Libertyville, Illinois 60048
United States
Condell Memorial Hospital
Libertyville, Illinois 60048
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
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Illinois CancerCare-Pekin
Pekin, Illinois 61554
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Illinois CancerCare-Peoria
Peoria, Illinois 61615
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Illinois CancerCare-Peru
Peru, Illinois 61354
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Illinois CancerCare-Princeton
Princeton, Illinois 61356
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UW Health Carbone Cancer Center Rockford
Rockford, Illinois 61114
United States
Memorial Hospital East
Shiloh, Illinois 62269
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Northwest Cancer Center – Crown Point
Crown Point, Indiana 46307
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Northwest Oncology LLC
Dyer, Indiana 46311
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Northwest Cancer Center – Hobart
Hobart, Indiana 46342
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Saint Mary Medical Center
Hobart, Indiana 46342
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Saint Catherine Hospital
Indianapolis, Indiana 46312
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The Community Hospital
Munster, Indiana 46321
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Women’s Diagnostic Center – Munster
Munster, Indiana 46321
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Northwest Cancer Center – Valparaiso
Valparaiso, Indiana 46383
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Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
Baptist Health Louisville
Louisville, Kentucky 40207
United States
Harold Alfond Center for Cancer Care
Augusta, Maine 04330
United States
National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
UMass Memorial Medical Center – University Campus
Worcester, Massachusetts 01655
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Bronson Battle Creek
Battle Creek, Michigan 49017
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
United States
Cancer and Hematology Centers of Western Michigan – Norton Shores
Norton Shores, Michigan 49444
United States
Hope Cancer Center
Pontiac, Michigan 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Corewell Health Reed City Hospital
Reed City, Michigan 49677
United States
Corewell Health Lakeland Hospitals – Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States
Munson Medical Center
Traverse City, Michigan 49684
United States
University of Michigan Health – West
Wyoming, Michigan 49519
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
MU Health – University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri 65212
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Saint Luke’s Hospital of Kansas City
Kansas City, Missouri 64111
United States
Saint Luke’s East – Lee’s Summit
Lee’s Summit, Missouri 64086
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89183
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New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
United States
Solinsky Center for Cancer Care
Manchester, New Hampshire 03103
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
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Morristown Medical Center
Morristown, New Jersey 07960
United States
Saint Joseph’s Regional Medical Center
Paterson, New Jersey 07503
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Overlook Hospital
Summit, New Jersey 07902
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
United States
Memorial Medical Center-Las Cruces
Las Cruces, New Mexico 88011
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Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York 14905
United States
Glens Falls Hospital
Glens Falls, New York 12801
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
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Memorial Sloan Kettering Cancer Center
New York, New York 10065
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Upstate Cancer Center at Oswego
Oswego, New York 13126
United States
Stony Brook University Medical Center
Stony Brook, New York 11794
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
SUNY Upstate Medical Center-Community Campus
Syracuse, New York 13215
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
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Upstate Cancer Center at Verona
Verona, New York 13478
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
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Levine Cancer Institute-SouthPark
Charlotte, North Carolina 28211
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Atrium Health University City/LCI-University
Charlotte, North Carolina 28262
United States
Levine Cancer Institute-Ballantyne
Charlotte, North Carolina 28277
United States
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
United States
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina 28025
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Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
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Atrium Health Lincoln/LCI-Lincolnton
Lincolnton, North Carolina 28092
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Atrium Health Cleveland/LCI-Cleveland
Shelby, North Carolina 28150
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Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
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Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Cleveland Clinic Akron General
Akron, Ohio 44307
United States
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Premier Blood and Cancer Center
Dayton, Ohio 45409
United States
Dayton Physician LLC – Englewood
Dayton, Ohio 45415
United States
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
United States
Kettering Medical Center
Kettering, Ohio 45429
United States
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
United States
North Coast Cancer Care
Sandusky, Ohio 44870
United States
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
United States
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
United States
Upper Valley Medical Center
Troy, Ohio 45373
United States
South Pointe Hospital
Warrensville Heights, Ohio 44122
United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
United States
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
United States
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
United States
Lehigh Valley Hospital – Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Penn State Health Medical Group – Andrews Patel Hematology/Oncology East
Harrisburg, Pennsylvania 17111
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Jefferson Methodist Hospital
Philadelphia, Pennsylvania 19148
United States
Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
United States
Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina 29732
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
United States
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota 57401
United States
Rapid City Regional Hospital
Rapid City, South Dakota 57701
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Avera Cancer Institute
Sioux Falls, South Dakota 57105
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Avera Cancer Institute at Yankton
Yankton, South Dakota 57078
United States
University Cancer Specialists – Alcoa
Alcoa, Tennessee 37701
United States
University of Tennessee – Knoxville
Knoxville, Tennessee 37920
United States
UT Southwestern Simmons Cancer Center – RedBird
Dallas, Texas 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
United States
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
United States
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
United States
Bon Secours Saint Mary’s Hospital
Richmond, Virginia 23226
United States
Virginia Cancer Institute
Richmond, Virginia 23229
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
VCU Community Memorial Health Center
South Hill, Virginia 23970
United States
Shenandoah Oncology PC
Winchester, Virginia 22601
United States
Valley Medical Center
Renton, Washington 98055
United States
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684
United States
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Cross Cancer Institute
Edmonton, Alberta T6G 1Z2
Canada
University Health Network-Princess Margaret Hospital
Toronto, Ontario M5G 2M9
Canada
Allan Blair Cancer Centre
Regina, Saskatchewan S4T 7T1
Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan S7N 4H4
Canada
Data Sources & Contacts
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