Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy
Study Acronym: GAIN-BCG
Study Information
Alliance Study ID: A032303
NCT Study ID (ClinicalTrials.gov): NCT07000084
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Genitourinary Cancers – Kidney / Bladder / Urothelial / Testicular
Alliance Study Chair: Eugene Pietzak, MD
Status: RECRUITING
Study Description
This phase III trial compares the effect of adding gemcitabine to intravesical Bacillus Calmette Guerin (BCG) versus intravesical BCG alone in patients with non-muscle invasive bladder cancer that has come back after a period of improvement (recurrent). Gemcitabine is a chemotherapy drug that blocks the cells from making deoxyribonucleic acid (DNA) and may kill cancer cells. Intravesical BCG is a solution containing the live BCG bacteria that is placed in the bladder via a catheter (intravesical). When the solution comes into direct contact with the bladder wall, it stimulates the body’s immune system which kills tumor cells. Giving gemcitabine with intravesical BCG may kill more tumor cells in patients with recurrent non-muscle invasive bladder cancer.
Related Publications
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Locations (58)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
Fairbanks Memorial Hospital
Fairbanks, Alaska 99701
United States
Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
UCI Health – Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
Sibley Memorial Hospital
Washington D.C., District of Columbia 20016
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Illinois
Chicago, Illinois 60612
United States
Loyola University Medical Center
Maywood, Illinois 60153
United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
United States
IU Health West Hospital
Avon, Indiana 46123
United States
IU Health North Hospital
Carmel, Indiana 46032
United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
United States
IU Health Methodist Hospital
Indianapolis, Indiana 46202
United States
Mary Bird Perkins Cancer Center – Metairie
Metairie, Louisiana 70002
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
United States
FMH James M Stockman Cancer Institute
Frederick, Maryland 21702
United States
Brigham and Women’s Hospital
Boston, Massachusetts 02115
United States
Lahey Clinic
Burlington, Massachusetts 01805
United States
Lahey Clinic Peabody
Peabody, Massachusetts 01960
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Great Falls Clinic
Great Falls, Montana 59405
United States
Hi-Line Sletten Cancer Center
Havre, Montana 59501
United States
Benefis Helena Specialty Center
Helena, Montana 59601
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Geisinger Medical Center
Danville, Pennsylvania 17822
United States
Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania 18519
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
Fox Chase Cancer Center-Rockledge
Rockledge, Pennsylvania 19046
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States
Ralph H Johnson VA Medical Center
Charleston, South Carolina 29401
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Memorial Hospital of Laramie County
Cheyenne, Wyoming 82001
United States
Billings Clinic-Cody
Cody, Wyoming 82414
United States
Data Sources & Contacts
Full trial details
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