Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working
Study Information
Alliance Study ID: A092104
NCT Study ID (ClinicalTrials.gov): NCT05432791
Alliance Committee: Experimental Therapeutics
Disease or Cancer Type: Gynecologic Cancers – Ovarian / Uterine / Cervical / Endometrial
Alliance Study Chair: Matthew Ingham
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II/III trial compares the effect of the combination treatment with olaparib and temozolomide to trabectedin or pazopanib (two of the most common chemotherapy drugs used as usual approach) in patients with uterine leiomyosarcoma that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) after initial chemotherapy has stopped working. The usual approach is defined as care most people get for advanced uterine leiomyosarcoma. Olaparib is a PARP inhibitor. PARP is a protein that helps repair damaged deoxyribonucleic acid (DNA). Blocking PARP may prevent tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Temozolomide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of tumor cells in the body. The combination of olaparib and temozolomide may work better than the usual treatment in shrinking or stabilizing advanced uterine leiomyosarcoma after initial chemotherapy has stopped working.
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Locations (145)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
Alaska Women’s Cancer Care
Anchorage, Alaska 99508
United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
Epic Care-Dublin
Dublin, California 94568
United States
Epic Care Partners in Cancer Care
Emeryville, California 94608
United States
City of Hope at Irvine Lennar
Irvine, California 92618
United States
Contra Costa Regional Medical Center
Martinez, California 94553-3156
United States
Epic Care Cyberknife Center
Walnut Creek, California 94597
United States
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
United States
Memorial Hospital North
Colorado Springs, Colorado 80920
United States
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado 80631
United States
Medical Center of the Rockies
Loveland, Colorado 80538
United States
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
United States
Smilow Cancer Hospital Care Center – Guilford
Guilford, Connecticut 06437
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States
Yale University
New Haven, Connecticut 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
United States
Smilow Cancer Hospital Care Center – Waterford
Waterford, Connecticut 06385
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia 20010
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324
United States
Lewis Cancer and Research Pavilion at Saint Joseph’s/Candler
Savannah, Georgia 31405
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Twin Falls
Twin Falls, Idaho 83301
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Illinois
Chicago, Illinois 60612
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa 51503
United States
Mercy Medical Center – Des Moines
Des Moines, Iowa 50314
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
Baptist Health Lexington
Lexington, Kentucky 40503
United States
Our Lady of the Lake Medical Oncology
Baton Rouge, Louisiana 70817
United States
University Medical Center New Orleans
New Orleans, Louisiana 70112
United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine 04074
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan 48109
United States
Bronson Battle Creek
Battle Creek, Michigan 49017
United States
Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
United States
Cancer and Hematology Centers of Western Michigan – Norton Shores
Norton Shores, Michigan 49444
United States
Corewell Health Reed City Hospital
Reed City, Michigan 49677
United States
Corewell Health Lakeland Hospitals – Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States
Munson Medical Center
Traverse City, Michigan 49684
United States
University of Michigan Health – West
Wyoming, Michigan 49519
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
Nebraska Cancer Specialists/Oncology Hematology West PC – MECC
Omaha, Nebraska 68114
United States
Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States
Oncology Associates PC
Omaha, Nebraska 68114
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
ECU Health Medical Center
Greenville, North Carolina 27834
United States
UH Seidman Cancer Center at UH Avon Health Center
Avon, Ohio 44011
United States
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio 44122
United States
Case Western Reserve University
Cleveland, Ohio 44106
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
United States
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
United States
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
United States
Women and Infants Hospital
Providence, Rhode Island 02905
United States
Smilow Cancer Hospital Care Center – Westerly
Westerly, Rhode Island 02891
United States
Saint Joseph’s/Candler – Bluffton Campus
Bluffton, South Carolina 29910
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Fred Hutchinson Cancer Center
Seattle, Washington 98109
United States
University of Washington Medical Center – Montlake
Seattle, Washington 98195
United States
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684
United States
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Centro Comprensivo de Cancer de UPR
San Juan, 00927
Puerto Rico
Data Sources & Contacts
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