Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
Study Information
Alliance Study ID: A052101
NCT Study ID (ClinicalTrials.gov): NCT05976763
Alliance Committee: Lymphoma
Disease or Cancer Type: Lymphoma
Alliance Study Chair: Anne Beaven, MD
Status: RECRUITING
Study Description
This phase III trial tests whether continuous or intermittent zanubrutinib after achieving a complete remission (CR) with rituximab works in older adult patients with mantle cell lymphoma (MCL) who have not received treatment in the past (previously untreated). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. When zanubrutinib is used in MCL, the current standard of care is to continue administering the drug indefinitely until disease progression. This continuous treatment comes with clinical as well as financial toxicity, which could be especially detrimental in older patients. For patients who achieve a CR after initial zanubrutinib plus rituximab therapy, it may be safe and equally effective to stop treatment and restart zanubrutinib upon disease progression rather than continuing indefinitely in previously untreated older adult patients with MCL.
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Locations (237)
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
United States
Tower Cancer Research Foundation
Beverly Hills, California 90211
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
City of Hope at Irvine Lennar
Irvine, California 92618
United States
Cedars-Sinai Medical Center
Los Angeles, California 90048
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
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Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
United States
Smilow Cancer Hospital Care Center – Guilford
Guilford, Connecticut 06437
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States
Yale University
New Haven, Connecticut 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
United States
Smilow Cancer Hospital Care Center – Waterford
Waterford, Connecticut 06385
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Phoebe Putney Memorial Hospital
Albany, Georgia 31701
United States
Grady Health System
Atlanta, Georgia 30303
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United States
Emory Saint Joseph’s Hospital
Atlanta, Georgia 30342
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Augusta University Medical Center
Augusta, Georgia 30912
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Emory Johns Creek Hospital
Johns Creek, Georgia 30097
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Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
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Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
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Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
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Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
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Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Alliance for Clinical Trials in Oncology
Chicago, Illinois 60606
United States
University of Illinois
Chicago, Illinois 60612
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
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Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
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Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Memorial Hospital East
Shiloh, Illinois 62269
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
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Carle Cancer Center
Urbana, Illinois 61801
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Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Northwest Cancer Center – Crown Point
Crown Point, Indiana 46307
United States
Northwest Oncology LLC
Dyer, Indiana 46311
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Northwest Cancer Center – Hobart
Hobart, Indiana 46342
United States
Saint Mary Medical Center
Hobart, Indiana 46342
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Saint Catherine Hospital
Indianapolis, Indiana 46312
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The Community Hospital
Munster, Indiana 46321
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Women’s Diagnostic Center – Munster
Munster, Indiana 46321
United States
Northwest Cancer Center – Valparaiso
Valparaiso, Indiana 46383
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
Saint Anthony Regional Hospital
Carroll, Iowa 51401
United States
UI Health Care Mission Cancer and Blood – West Des Moines Clinic
Clive, Iowa 50325
United States
Iowa Methodist Medical Center
Des Moines, Iowa 50309
United States
UI Health Care Mission Cancer and Blood – Des Moines Clinic
Des Moines, Iowa 50309
United States
Broadlawns Medical Center
Des Moines, Iowa 50314
United States
Mercy Medical Center – Des Moines
Des Moines, Iowa 50314
United States
UI Health Care Mission Cancer and Blood – Laurel Clinic
Des Moines, Iowa 50314
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
UI Healthcare Mission Cancer and Blood – Fort Dodge
Fort Dodge, Iowa 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
HaysMed
Hays, Kansas 67601
United States
University of Kansas Cancer Center
Kansas City, Kansas 66160
United States
Lawrence Memorial Hospital
Lawrence, Kansas 66044
United States
Veteran Administration Eastern Kansas Healthcare
Leavenworth, Kansas 66048
United States
The University of Kansas Cancer Center – Olathe
Olathe, Kansas 66061
United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
United States
Freeman Physician Group of Pittsburg
Pittsburg, Kansas 66762
United States
Salina Regional Health Center
Salina, Kansas 67401
United States
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
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UofL Health Medical Center Northeast
Louisville, Kentucky 40245
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
McLaren Cancer Institute-Bay City
Bay City, Michigan 48706
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
McLaren Cancer Institute-Clarkston
Clarkston, Michigan 48346
United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
United States
Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan 48336
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
McLaren Cancer Institute-Flint
Flint, Michigan 48532
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan 48446
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
United States
McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan 48858
United States
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan 49770
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan 48073
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan 48085
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Saint Mary’s Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
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Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
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Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
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Essentia Health Saint Joseph’s Medical Center
Brainerd, Minnesota 56401
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Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Essentia Health – Deer River Clinic
Deer River, Minnesota 56636
United States
Essentia Health Cancer Center
Duluth, Minnesota 55805
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
United States
Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
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Hennepin County Medical Center
Minneapolis, Minnesota 55415
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Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
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Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
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United Hospital
Saint Paul, Minnesota 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota 55072
United States
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
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Saint Francis Medical Center
Cape Girardeau, Missouri 63703
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Saint Luke’s Hospital
Chesterfield, Missouri 63017
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Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
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Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
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University Health Truman Medical Center
Kansas City, Missouri 64108
United States
University of Kansas Cancer Center – Briarcliff
Kansas City, Missouri 64116
United States
Kansas City Veterans Affairs Medical Center
Kansas City, Missouri 64128
United States
University of Kansas Cancer Center – North
Kansas City, Missouri 64154
United States
University of Kansas Cancer Center – Lee’s Summit
Lee’s Summit, Missouri 64064
United States
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri 64116
United States
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
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Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska 68123
United States
Fred and Pamela Buffett Cancer Center – Kearney
Kearney, Nebraska 68845
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Hematology Oncology Associates of CNY at Camillus
Camillus, New York 13031
United States
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York 13057
United States
NYU Langone Hospital – Long Island
Mineola, New York 11501
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
United States
NYP/Weill Cornell Medical Center
New York, New York 10065
United States
University of Rochester
Rochester, New York 14642
United States
Wilmot Cancer Institute at Webster
Webster, New York 14580
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
United States
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Rhode Island Hospital
Providence, Rhode Island 02903
United States
Smilow Cancer Hospital Care Center – Westerly
Westerly, Rhode Island 02891
United States
Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
United States
Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
Dartmouth Cancer Center – North
Saint Johnsbury, Vermont 05819
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
United States
ThedaCare Regional Medical Center – Appleton
Appleton, Wisconsin 54911
United States
Duluth Clinic Ashland
Ashland, Wisconsin 54806
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
University of Wisconsin Carbone Cancer Center – Johnson Creek
Johnson Creek, Wisconsin 53038
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
University of Wisconsin Carbone Cancer Center – Eastpark Medical Center
Madison, Wisconsin 53718
United States
University of Wisconsin Carbone Cancer Center – University Hospital
Madison, Wisconsin 53792
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, Wisconsin 53151
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
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