Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
Study Acronym: BRCA-P
Study Information
Alliance Study ID: A211801
NCT Study ID (ClinicalTrials.gov): NCT04711109
Alliance Committee: Breast Cancer
Disease or Cancer Type: Breast Cancer
Alliance Study Chair: Judy E. Garber, MD, MPH
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase III trial compares denosumab to placebo for the prevention of breast cancer in women with a BRCA1 germline mutation. A germline mutation is an inherited gene change which, in the BRCA1 gene, is associated with an increased risk of breast and other cancers. Denosumab is a monoclonal antibody that is used to treat bone loss in order to reduce the risk of bone fractures in healthy people, and to reduce new bone growths in cancer patients whose cancer has spread to their bones. Research has shown that denosumab may also reduce the risk of developing breast cancer in women carrying a BRCA1 germline mutation.
Related Publications
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Locations (47)
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
UCSF Medical Center-Mount Zion
San Francisco, California 94115
United States
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
United States
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
United States
Rocky Mountain Cancer Centers – Centennial
Centennial, Colorado 80112
United States
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
United States
Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
United States
Mountain Blue Cancer Care Center – Swedish
Englewood, Colorado 80113
United States
Rocky Mountain Cancer Centers – Swedish
Englewood, Colorado 80113
United States
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
United States
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas 66211
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
Maine Medical Center- Scarborough Campus
Scarborough, Maine 04074
United States
Maine Medical Partners – South Portland
South Portland, Maine 04106
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United States
Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
United States
Novant Health Breast Surgery – Greensboro
Greensboro, North Carolina 27403
United States
Novant Health Cancer Institute – Kernersville
Kernersville, North Carolina 27284
United States
Novant Health Cancer Institute – Mount Airy
Mount Airy, North Carolina 27030
United States
Novant Health Cancer Institute – Thomasville
Thomasville, North Carolina 27360
United States
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina 27103
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania 19104
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
M D Anderson Cancer Center
Houston, Texas 77030
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
University of Vermont Medical Center
Burlington, Vermont 05401
United States
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
United States
Data Sources & Contacts
Full trial details
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