Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
Study Information
Alliance Study ID: A031102
NCT Study ID (ClinicalTrials.gov): NCT02375204
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Genitourinary Cancers – Kidney / Bladder / Urothelial / Testicular
Alliance Study Chair: Darren Feldman, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors.
Related Publications
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Locations (125)
Children’s Hospital of Alabama
Birmingham, Alabama 35233
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
Loma Linda University Medical Center
Loma Linda, California 92354
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Kaiser Permanente-Oakland
Oakland, California 94611
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
United States
UCSF Medical Center-Mission Bay
San Francisco, California 94158
United States
Alfred I duPont Hospital for Children
Wilmington, Delaware 19803
United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
University of Florida Health Science Center – Gainesville
Gainesville, Florida 32610
United States
Nemours Children’s Clinic-Jacksonville
Jacksonville, Florida 32207
United States
Nicklaus Children’s Hospital
Miami, Florida 33155
United States
Miami Cancer Institute
Miami, Florida 33176
United States
Arnold Palmer Hospital for Children
Orlando, Florida 32806
United States
Johns Hopkins All Children’s Hospital
St. Petersburg, Florida 33701
United States
Saint Joseph’s Hospital/Children’s Hospital-Tampa
Tampa, Florida 33607
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United States
Northwestern University
Chicago, Illinois 60611
United States
Rush University Medical Center
Chicago, Illinois 60612
United States
University of Illinois
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
United States
Cancer Center of Kansas – Wichita
Wichita, Kansas 67214
United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United States
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
United States
University of Michigan Health – West
Wyoming, Michigan 49519
United States
Children’s Hospitals and Clinics of Minnesota – Minneapolis
Minneapolis, Minnesota 55404
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Saint Joseph’s Regional Medical Center
Paterson, New Jersey 07503
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
United States
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio 45229
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania 19104
United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania 19104
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
Rhode Island Hospital
Providence, Rhode Island 02903
United States
Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
United States
Saint Francis Hospital
Greenville, South Carolina 29601
United States
BI-LO Charities Children’s Cancer Center
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Saint Francis Cancer Center
Greenville, South Carolina 29607
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
Saint Jude Children’s Research Hospital
Memphis, Tennessee 38105
United States
The Children’s Hospital at TriStar Centennial
Nashville, Tennessee 37203
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
El Paso Children’s Hospital
El Paso, Texas 79905
United States
M D Anderson Cancer Center
Houston, Texas 77030
United States
Seattle Children’s Hospital
Seattle, Washington 98105
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
Australia
Princess Alexandra Hospital
Woolloongabba, Queensland 4102
Australia
Box Hill Hospital
Box Hill, Victoria 3128
Australia
Peter MacCallum Cancer Centre
Melbourne, Victoria 3000
Australia
Institut Jules Bordet
Anderlecht, 1070
Belgium
University Hospital Saint Luc
Brussels, 1200
Belgium
Rigshospitalet University Hospital
Copenhagen, 2100
Denmark
Centre Leon Berard
Lyon, 69373
France
Institut Paoli Calmettes
Marseille, 13273
France
Hopital Tenon/Assistance Publique – Hopitaux de Paris
Paris, 75970
France
CHRU Strasbourg – Hospital Civil
Strasbourg, 67091
France
Center Claudius Regaud
Toulouse, 31052
France
Centre Alexis Vautrin
Vandœuvre-lès-Nancy, 54511
France
Gustave Roussy
Villejuif, 94805
France
Technical University Dresden
Dresden, Saxony 01307
Germany
University of Berlin Charite Campus Benjamin Franklin
Berlin, 12203
Germany
University of Dusseldorf
Düsseldorf, 40225
Germany
University of Essen
Essen, 45122
Germany
University Medical Center Hamburg-Eppendorf
Hamburg, 20246
Germany
UniversitaetsKlinikum Heidelberg
Heidelberg, 69120
Germany
GK-Mittelrhein Saint Martin’s
Koblenz, 56068
Germany
Philipps University Marburg
Marburg, 35033
Germany
Rotkreuzklinikum Munchen
Munich, 80634
Germany
Klinikum Nurnberg Nord
Nuremberg, 90419
Germany
University Hospital Ulm
Ulm, 89081
Germany
Saint James Hospital
Dublin, 8
Ireland
Ospedale di Circolo di Busto Arsizio
Busto Arsizio, 21052
Italy
Istituto Scientifico Romagnolo
Meldola, 47014
Italy
Istituto Nazionale Tumori
Milan, 20133
Italy
San Matteo Hospital
Pavia, 27100
Italy
The Netherlands Cancer Institute
Amsterdam, 1066 CX
Netherlands
University Medical Center Groningen
Groningen, 9700 GZ
Netherlands
Radboud University Nijmegen Medical Centre
Nijmegen, 6500 HB
Netherlands
Hospital De La Santa Creu I Sant Pau
Barcelona, 08025
Spain
Duran i Reynals Hospital-Catalan Institute of Oncology
Barcelona, 08908
Spain
Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
Hospital General Universitario Morales Meseguer
Murcia, 30008
Spain
Inselspital
Bern, 3010
Switzerland
Hopitaux Universitaires de Geneve
Geneva, 1211
Switzerland
University Hospital Zurich
Zurich, 8091
Switzerland
Saint Bartholomew’s Hospital
London, England EC1A 7BE
United Kingdom
Christie Hospital
Manchester, England M20 4BX
United Kingdom
Weston Park Hospital
Sheffield, England S10 2SJ
United Kingdom
Southampton General Hospital
Southampton, England SO16 6YD
United Kingdom
Saint James’s University Hospital
West Yorkshire, England LS9 7TF
United Kingdom
Beatson Oncology Center
Glasgow, Scotland G12 0YN
United Kingdom
Nottingham City Hospital
Nottingham, NG5 1PB
United Kingdom
The Royal Marsden NHS Foundation Trust – Sutton
Surrey, SM2 5PT
United Kingdom
Data Sources & Contacts
Full trial details
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