Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia
Study Information
Alliance Study ID: A041703
NCT Study ID (ClinicalTrials.gov): NCT03739814
Alliance Committee: Leukemia
Disease or Cancer Type: Leukemia & Myelodysplastic Syndromes (MDS)
Alliance Study Chair: Matthew J Wieduwilt
Status: RECRUITING
Study Description
This phase II trial studies how well inotuzumab ozogamicin and blinatumomab with or without ponatinib work in treating patients with CD22-positive B-lineage acute lymphoblastic leukemia that is newly diagnosed, has come back after a period of improvement (recurrent), or does not respond to treatment (refractory). Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug, called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Blinatumomab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Ponatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving inotuzumab ozogamicin and blinatumomab with or without ponatinib may be effective in treating patients with newly diagnosed, recurrent or refractory CD22 positive B-lineage acute lymphoblastic leukemia.
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
Locations (277)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
United States
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
United States
Alaska Women’s Cancer Care
Anchorage, Alaska 99508
United States
Anchorage Oncology Centre
Anchorage, Alaska 99508
United States
Katmai Oncology Group
Anchorage, Alaska 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
Kingman Regional Medical Center
Kingman, Arizona 86401
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
United States
PCR Oncology
Arroyo Grande, California 93420
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
United States
Community Cancer Institute
Clovis, California 93611
United States
University Oncology Associates
Clovis, California 93611
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
UCI Health – Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
United States
Beebe Medical Center
Lewes, Delaware 19958
United States
Beebe South Coastal Health Campus
Millville, Delaware 19967
United States
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware 19713
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
United States
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
TidalHealth Nanticoke / Allen Cancer Center
Seaford, Delaware 19973
United States
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware 19801
United States
MedStar Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
Holy Cross Hospital
Fort Lauderdale, Florida 33308
United States
Jupiter Medical Center
Jupiter, Florida 33458
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United States
Emory Saint Joseph’s Hospital
Atlanta, Georgia 30342
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Twin Falls
Twin Falls, Idaho 83301
United States
OSF Saint Anthony’s Health Center
Alton, Illinois 62002
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois 60527
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States
SIH Cancer Institute
Carterville, Illinois 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Illinois
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Loyola Medicine Homer Glen
Homer Glen, Illinois 60491
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Loyola University Medical Center
Maywood, Illinois 60153
United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
United States
SSM Health Good Samaritan
Mount Vernon, Illinois 62864
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
OSF Saint Francis Radiation Oncology at Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States
OSF Saint Francis Medical Center
Peoria, Illinois 61637
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Valley Radiation Oncology
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Central Care Cancer Center – Garden City
Garden City, Kansas 67846
United States
Central Care Cancer Center – Great Bend
Great Bend, Kansas 67530
United States
University of Kansas Cancer Center
Kansas City, Kansas 66160
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
United States
Mercy Medical Center
Springfield, Massachusetts 01104
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Caro Cancer Center
Caro, Michigan 48723
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan 48236
United States
Henry Ford River District Hospital
East China Township, Michigan 48054
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
Henry Ford Saint John Hospital – Academic
Grosse Pointe Woods, Michigan 48236
United States
Henry Ford Saint John Hospital – Breast
Grosse Pointe Woods, Michigan 48236
United States
Henry Ford Saint John Hospital – Van Elslander
Grosse Pointe Woods, Michigan 48236
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Hope Cancer Clinic
Livonia, Michigan 48154
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
United States
Henry Ford Warren Hospital – Breast Macomb
Macomb, Michigan 48044
United States
Saint Mary’s Oncology/Hematology Associates of Marlette
Marlette, Michigan 48453
United States
Hope Cancer Center
Pontiac, Michigan 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Henry Ford Rochester Hospital
Rochester Hills, Michigan 48309
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
United States
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan 48312
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
United States
Advanced Breast Care Center PLLC
Warren, Michigan 48088
United States
Henry Ford Health Warren Hospital
Warren, Michigan 48093
United States
Henry Ford Madison Heights Hospital – Breast
Warren, Michigan 48093
United States
Henry Ford Warren Hospital – GLCMS
Warren, Michigan 48093
United States
Macomb Hematology Oncology PC
Warren, Michigan 48093
United States
Saint Mary’s Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Mercy Oncology and Hematology – Clayton-Clarkson
Ballwin, Missouri 63011
United States
Central Care Cancer Center – Bolivar
Bolivar, Missouri 65613
United States
Cox Cancer Center Branson
Branson, Missouri 65616
United States
Mercy Cancer Center – Cape Girardeau
Cape Girardeau, Missouri 63703
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri 65109
United States
Freeman Health System
Joplin, Missouri 64804
United States
Mercy Hospital Joplin
Joplin, Missouri 64804
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
United States
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Mercy Infusion Center – Chippewa
St Louis, Missouri 63109
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Mercy Hospital Washington
Washington, Missouri 63090
United States
Saint Patrick Hospital – Community Hospital
Missoula, Montana 59802
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
United States
Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
United States
Comprehensive Cancer Centers of Nevada – Henderson
Henderson, Nevada 89052
United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
United States
Las Vegas Cancer Center-Henderson
Henderson, Nevada 89052
United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
United States
Las Vegas Urology – Green Valley
Henderson, Nevada 89074
United States
Las Vegas Urology – Pebble
Henderson, Nevada 89074
United States
Oncology Las Vegas – Henderson
Henderson, Nevada 89074
United States
Urology Specialists of Nevada – Green Valley
Henderson, Nevada 89074
United States
Las Vegas Urology – Pecos
Las Vegas, Nevada 89074
United States
Desert West Surgery
Las Vegas, Nevada 89102
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States
University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
United States
Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
United States
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
United States
Urology Specialists of Nevada – Central
Las Vegas, Nevada 89106
United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, Nevada 89109
United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, Nevada 89113
United States
Las Vegas Prostate Cancer Center
Las Vegas, Nevada 89113
United States
Las Vegas Urology – Sunset
Las Vegas, Nevada 89113
United States
Urology Specialists of Nevada – Southwest
Las Vegas, Nevada 89113
United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
United States
Ann M Wierman MD LTD
Las Vegas, Nevada 89128
United States
Comprehensive Cancer Centers of Nevada – Northwest
Las Vegas, Nevada 89128
United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, Nevada 89128
United States
Las Vegas Urology – Cathedral Rock
Las Vegas, Nevada 89128
United States
Las Vegas Urology – Smoke Ranch
Las Vegas, Nevada 89128
United States
Oncology Las Vegas – Tenaya
Las Vegas, Nevada 89128
United States
OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
United States
Urology Specialists of Nevada – Northwest
Las Vegas, Nevada 89128
United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada 89135
United States
Comprehensive Cancer Centers of Nevada – Town Center
Las Vegas, Nevada 89144
United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
United States
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
United States
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada 89148-2405
United States
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, Nevada 89149
United States
Comprehensive Cancer Centers of Nevada – Central Valley
Las Vegas, Nevada 89169
United States
University Cancer Center
Las Vegas, Nevada 89169
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89183
United States
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
United States
Renown Regional Medical Center
Reno, Nevada 89502
United States
Saint Mary’s Regional Medical Center
Reno, Nevada 89503
United States
Radiation Oncology Associates
Reno, Nevada 89509
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
North Shore University Hospital
Manhasset, New York 11030
United States
Long Island Jewish Medical Center
New Hyde Park, New York 11040
United States
NYP/Weill Cornell Medical Center
New York, New York 10065
United States
University of Rochester
Rochester, New York 14642
United States
Stony Brook University Medical Center
Stony Brook, New York 11794
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
East Carolina University
Greenville, North Carolina 27834
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Saint Charles Health System
Bend, Oregon 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
United States
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
United States
Bay Area Hospital
Coos Bay, Oregon 97420
United States
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
Saint Charles Health System-Redmond
Redmond, Oregon 97756
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
United States
Lehigh Valley Hospital – Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
United States
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
United States
Overlake Medical Center
Bellevue, Washington 98004
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington 98632
United States
Valley Medical Center
Renton, Washington 98055
United States
Pacific Gynecology Specialists
Seattle, Washington 98104
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
United States
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
United States
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington 98902
United States
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
United States
West Virginia University Healthcare
Morgantown, West Virginia 26506
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
University of Wisconsin Carbone Cancer Center – Eastpark Medical Center
Madison, Wisconsin 53718
United States
University of Wisconsin Carbone Cancer Center – University Hospital
Madison, Wisconsin 53792
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, Wisconsin 53151
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
San Juan City Hospital
San Juan, 00936
Puerto Rico
Data Sources & Contacts
Full trial details
For more Information