Comparing Capecitabine and Temozolomide in Combination to Lutetium Lu 177 Dotatate in Patients With Advanced Pancreatic Neuroendocrine Tumors
Study Information
Alliance Study ID: A022001
NCT Study ID (ClinicalTrials.gov): NCT05247905
Alliance Committee: Gastrointestinal Cancer
Disease or Cancer Type: Gastrointestinal Cancers – Pancreatic / Gastric / Esophageal / Liver / Biliary
Alliance Study Chair: Timothy J. b, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II trial compares capecitabine and temozolomide to lutetium Lu 177 dotatate for the treatment of pancreatic neuroendocrine tumors that have spread to other parts of the body (advanced) or are not able to be removed by surgery (unresectable). Chemotherapy drugs, such as capecitabine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radioactive drugs, such as lutetium Lu 177 dotatate, may carry radiation directly to tumor cells and may reduce harm to normal cells. The purpose of this study is to find out whether capecitabine and temozolomide or lutetium Lu 177 dotatate may kill more tumor cells in patients with advanced pancreatic neuroendocrine tumors.
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Locations (171)
Fairbanks Memorial Hospital
Fairbanks, Alaska 99701
United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
Tower Cancer Research Foundation
Beverly Hills, California 90211
United States
Epic Care-Dublin
Dublin, California 94568
United States
Bay Area Breast Surgeons Inc
Emeryville, California 94608
United States
Epic Care Partners in Cancer Care
Emeryville, California 94608
United States
Cedars Sinai Medical Center
Los Angeles, California 90048
United States
Contra Costa Regional Medical Center
Martinez, California 94553-3156
United States
Bay Area Tumor Institute
Oakland, California 94609
United States
Torrance Memorial Physician Network – Cancer Care
Torrance, California 90505
United States
Epic Care Cyberknife Center
Walnut Creek, California 94597
United States
BASS Medical Group – Lennon
Walnut Creek, California 94598
United States
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
United States
Boulder Community Foothills Hospital
Boulder, Colorado 80303
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
United States
Rocky Mountain Cancer Centers – Centennial
Centennial, Colorado 80112
United States
The Women’s Imaging Center
Denver, Colorado 80209
United States
Colorado Blood Cancer Institute
Denver, Colorado 80218
United States
Presbyterian – Saint Lukes Medical Center – Health One
Denver, Colorado 80218
United States
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
United States
Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
United States
Mountain Blue Cancer Care Center – Swedish
Englewood, Colorado 80113
United States
Rocky Mountain Cancer Centers – Swedish
Englewood, Colorado 80113
United States
The Melanoma and Skin Cancer Institute
Englewood, Colorado 80113
United States
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado 80228
United States
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
United States
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
United States
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado 80501
United States
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado 80260
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
United States
Smilow Cancer Hospital Care Center – Guilford
Guilford, Connecticut 06437
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States
Yale University
New Haven, Connecticut 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
United States
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477
United States
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
United States
Smilow Cancer Hospital Care Center – Waterford
Waterford, Connecticut 06385
United States
Sibley Memorial Hospital
Washington D.C., District of Columbia 20016
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Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
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Advocate Outpatient Center – Aurora
Aurora, Illinois 60506
United States
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
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Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
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SIH Cancer Institute
Carterville, Illinois 62918
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Illinois CancerCare-Carthage
Carthage, Illinois 62321
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Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Illinois
Chicago, Illinois 60612
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
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Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
AMG Crystal Lake – Oncology
Crystal Lake, Illinois 60014
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Advocate Sherman Hospital
Elgin, Illinois 60123
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
AMG Libertyville – Oncology
Libertyville, Illinois 60048
United States
Condell Memorial Hospital
Libertyville, Illinois 60048
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
United States
Advocate Outpatient Center – Oak Lawn
Oak Lawn, Illinois 60453
United States
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Valley Radiation Oncology
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
Mercy Health – Paducah Cancer Center
Paducah, Kentucky 42003
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
United States
Boston Medical Center
Boston, Massachusetts 02118
United States
Hickman Cancer Center
Adrian, Michigan 49221
United States
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan 48162
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Sanford Cancer Center Worthington
Worthington, Minnesota 56187
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
United States
Mercy Cancer Center – Cape Girardeau
Cape Girardeau, Missouri 63703
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri 65109
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska 68123
United States
Cancer Partners of Nebraska
Lincoln, Nebraska 68516
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
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Mount Sinai Hospital
New York, New York 10029
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
Montefiore Medical Center-Einstein Campus
The Bronx, New York 10461
United States
Montefiore Medical Center-Weiler Hospital
The Bronx, New York 10461
United States
Montefiore Medical Center – Moses Campus
The Bronx, New York 10467
United States
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio 43537
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Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
United States
Saint Vincent Hospital
Erie, Pennsylvania 16544
United States
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
United States
Forbes Hospital
Monroeville, Pennsylvania 15146
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Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
United States
West Penn Hospital
Pittsburgh, Pennsylvania 15224
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
United States
Smilow Cancer Hospital Care Center – Westerly
Westerly, Rhode Island 02891
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Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
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Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
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Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
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Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
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Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
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Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
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Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
Jefferson Healthcare
Port Townsend, Washington 98368
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin 54729
United States
Aurora Saint Luke’s South Shore
Cudahy, Wisconsin 53110
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Aurora Health Center – Greenfield
Greenfield, Wisconsin 53228
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Marshfield Medical Center – Ladysmith
Ladysmith, Wisconsin 54848
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
Marshfield Clinic-Wausau Center
Wausau, Wisconsin 54401
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Marshfield Clinic – Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin 54494
United States
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