Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS
Study Acronym: COMET
Study Information
Alliance Study ID: AFT-25
NCT Study ID (ClinicalTrials.gov): NCT02926911
Alliance Committee: Breast Cancer
Disease or Cancer Type: Breast Cancer
Alliance Study Chair: Ann Partridge, MD, MPH; Alastair Thompson, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM approach does not yield inferior cancer or quality of life outcomes compared to surgery.
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
Locations (141)
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
Mayo Clinic
Phoenix, Arizona 85054
United States
City of Hope
Duarte, California 91010
United States
Cedars-Sinai Medical Center
Los Angeles, California 90048
United States
Sharp Memorial Hospital
San Diego, California 92123
United States
Kaiser Permanente Medical Center
Vallejo, California 94589
United States
Colorado Cancer Research Program
Denver, Colorado 80222
United States
Saint Joseph Hospital- Cancer Centers of Colorado
Lafayette, Colorado 80026
United States
Smilow Cancer Hospital at Yale-New Haven
New Haven, Connecticut 06510
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia 20010
United States
Memorial Healthcare System
Hollywood, Florida 33021
United States
Mayo Clinic Florida
Jacksonville, Florida 32224
United States
University of Hawaii Cancer Center
Honolulu, Hawaii 96813
United States
Kootenai Health
Post Falls, Idaho 83854
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
United States
University of Chicago Medical Center
Chicago, Illinois 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States
Ingalls Memorial Hospital
Harvey, Illinois 60426
United States
Illinois Cancer Care
Peoria, Illinois 61615
United States
OSF Saint Anthony Medical Center
Rockford, Illinois 61108
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Medical Oncology and Hematology Associates – Des Moines
Des Moines, Iowa 50314
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States
University of Kansas Cancer Center
Kansas City, Kansas 66160
United States
St. Elizabeth Healthcare Edgewood
Edgewood, Kentucky 41017
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
United States
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
United States
Eastern Maine Medical Center Cancer Care
Brewer, Maine 04412
United States
Maine Center for Cancer Medicine-Scarborough
Scarborough, Maine 04074
United States
New England Cancer Specialists
Scarborough, Maine 04074
United States
Anne Arundel Medical Center
Annapolis, Maryland 21401
United States
University of Maryland – Greenebaum Comprehensive Cancer Center
Baltimore, Maryland 21201
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48197
United States
Henry Ford Hospital
Detroit, Michigan 48202
United States
Cancer Research Consortium of West Michigan
Grand Rapids, Michigan 49503
United States
Beaumont NCORP
Royal Oak, Michigan 48073
United States
Masonic Cancer Center, University of Minnesota
Minneapolis, Minnesota 55455
United States
Mayo Clinic
Rochester, Minnesota 55905
United States
Metro MN Community Oncology Research Consortium (MMCORC)
Saint Louis Park, Minnesota 55416
United States
Washington University – Siteman Cancer Center
St Louis, Missouri 63110
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic
Billings, Montana 59101
United States
Bozeman Health
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Kalispell Regional Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
New Hampshire Oncology Hematology PA
Hooksett, New Hampshire 03106
United States
Englewood Hospital and Medical Center
Englewood, New Jersey 07631
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Atlantic Health System / Morristown Medical Center
Morristown, New Jersey 07960
United States
Jersey Shore University Medical Center
Neptune City, New Jersey 07753
United States
The Valley Hospital – Luckow Pavilion
Paramus, New Jersey 07652
United States
New Mexico Cancer Care Alliance
Albuquerque, New Mexico 87106
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
New York-Presbyterian Weill Cornell Medical Center
New York, New York 10065
United States
Mount Sinai Hospital
New York, New York 60608
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
Montefiore-Einstein Center for Cancer Care at Montefiore Medical Park
The Bronx, New York 10461
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Levine Cancer Institute
Charlotte, North Carolina 28204
United States
Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Cape Fear Valley Health System
Fayetteville, North Carolina 28304
United States
Southeastern Medical Oncology Center
Goldsboro, North Carolina 27534
United States
Cone Health Cancer Center
Greensboro, North Carolina 27403
United States
Novant Health Breast Surgery – Greensboro
Greensboro, North Carolina 27403
United States
East Carolina University
Greenville, North Carolina 27834
United States
Carolina East Medical Center
New Bern, North Carolina 28561
United States
Rex Cancer Center
Raleigh, North Carolina 27607
United States
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina 27157
United States
Strecker Cancer Center – Belpre
Belpre, Ohio 45714
United States
Dayton Physicians-Miami Valley Hospital South
Centerville, Ohio 45459
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43202
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Mount Carmel East Hospital
Columbus, Ohio 43213
United States
Columbus Oncology & Hematology INC
Columbus, Ohio 43214
United States
Riverside Methodist Hospital
Columbus, Ohio 43214
United States
Grant Medical Center
Columbus, Ohio 43215
United States
MidOhio Oncology Hematology, Mark H. Zangmeister Center
Columbus, Ohio 43219
United States
Mount Carmel West Hospital
Columbus, Ohio 43223
United States
Doctors Hospital
Columbus, Ohio 43228
United States
Dayton Physicians-Miami Valley Hospital North
Dayton, Ohio 45415
United States
Grady Hospital
Delaware, Ohio 43015
United States
OhioHealth Grady – Delaware Health Center
Delaware, Ohio 43015
United States
Armes Family Cancer Center
Findlay, Ohio 45840
United States
Dayton Physicians-Atrium
Franklin, Ohio 45005
United States
Wayne Hospital
Greenville, Ohio 45331
United States
Kettering Medical Center
Kettering, Ohio 45429
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
United States
Marietta Memorial Hospital
Marietta, Ohio 45750
United States
OhioHealth Marion General Hospital
Marion, Ohio 43302
United States
Licking Memorial Hospital
Newark, Ohio 43055
United States
St. Ann’s Hospital
Westerville, Ohio 43081
United States
St. Elizabeth Youngstown Hospital
Youngstown, Ohio 44501
United States
Genesis Health Care System
Zanesville, Ohio 43701
United States
Cancer Centers of Southwest Oklahoma
Lawton, Oklahoma 73505
United States
Saint Charles Health System
Bend, Oregon 97701
United States
Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania 15213
United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
United States
WellSpan Health York Cancer Center
York, Pennsylvania 17403
United States
Rhode Island Hospital
Providence, Rhode Island 02906
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Georgetown Hospital System
Georgetown, South Carolina 29440
United States
Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Baptist Cancer Care
Memphis, Tennessee 38120
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75235
United States
Baylor University Medical Center
Dallas, Texas 75246
United States
MD Anderson Cancer Center
Houston, Texas 60586
United States
Doctors Hospital of Laredo
Laredo, Texas 78045
United States
Huntsman Cancer Institute
Salt Lake City, Utah 84112
United States
The University of Vermont Medical Center
Burlington, Vermont 05401
United States
West Virginia University Medicine
Morgantown, Virginia 26506
United States
Sentara Norfolk General Hospital
Norfolk, Virginia 23507
United States
Virginia Commonwealth University Massey Cancer Center
Richmond, Virginia 23298
United States
Overlake Hospital Medical Center
Bellevue, Washington 98004
United States
ThedaCare Regional Cancer Center -Appleton
Appleton, Wisconsin 54911
United States
Aurora Health Care, Aurora Cancer Care
Burlington, Wisconsin 53105
United States
Aurora Health Center – Fond du Lac
Fond du Lac, Wisconsin 54937
United States
Aurora Health Care, Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Health Care, Aurora Cancer Care
Grafton, Wisconsin 53024
United States
Saint Vincent Hospital
Green Bay, Wisconsin 54301
United States
BayCare Aurora LLC, Aurora Cancer Care
Green Bay, Wisconsin 54311
United States
Aurora Health Care, Aurora Cancer Care
Kenosha, Wisconsin 49408
United States
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United States
Aurora Bay Area Medical Group – Cancer Care Clinic
Marinette, Wisconsin 54143
United States
Aurora Health Care, Aurora Cancer Care
Marinette, Wisconsin 54143
United States
Aurora Health Care, Aurora Cancer Care
Milwaukee, Wisconsin 53209
United States
Vince Lombardi Cancer Clinic of Aurora St. Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Aurora Health Care, Aurora Cancer Care
Milwaukee, Wisconsin 53233
United States
Aurora Health Care, Aurora Cancer Care
Oshkosh, Wisconsin 54904
United States
Aurora Health Care, Aurora Cancer Care
Racine, Wisconsin 53406
United States
Aurora Health Care, Aurora Cancer Care
Sheboygan, Wisconsin 53081
United States
Aurora Health Care, Aurora Cancer Care
Summit, Wisconsin 53066
United States
Aurora Health Care, Aurora Cancer Care
Two Rivers, Wisconsin 54241
United States
Aurora Health Care, Aurora Cancer Care
Wauwatosa, Wisconsin 53226
United States
Aurora Health Care, Aurora Cancer Care
West Allis, Wisconsin 53227
United States
Data Sources & Contacts
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