Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial
Study Information
Alliance Study ID: A032304
NCT Study ID (ClinicalTrials.gov): NCT07200830
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Prostate Cancer
Alliance Study Chair: Thomas Hope, MD
Status: RECRUITING
Study Description
This randomized phase III trial examines whether lengthening the dosage interval in an adaptive manner for the prostate cancer drug lutetium 177 Lu PSMA RLT improves quality of life without decreasing lifespan when compared to the standard way this medication is given. This study is for patients with hormone resistant prostate cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body. Hormone resistant prostate cancer often has many cells containing a protein called prostate-specific membrane antigen (PSMA) on their surface. The normal cells in the prostate do not normally express as much PSMA protein on their surface as cancer cells. Lutetium 177 Lu PSMA RLT binds to the PSMA protein on the tumor cells. It builds up in these cells and gives off radiation that may kill them. Typically, this medication is given at the same dose every 6 weeks for up to 6 doses. In this trial, researchers want to see if treatment following the first two doses of lutetium 177 Lu PSMA RLT can be delayed until there is evidence of disease activity. This may be an effective way to improve quality of life without decreasing lifespan in patients with advanced prostate cancer.
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Locations (102)
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California 93301
United States
UCI Health – Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
United States
City of Hope at Irvine Lennar
Irvine, California 92618
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
CTCA at Southeastern Regional Medical Center
Newnan, Georgia 30265
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Northwestern University
Chicago, Illinois 60611
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
HSHS Saint Elizabeth’s Hospital
O’Fallon, Illinois 62269
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Midwestern Regional Medical Center
Zion, Illinois 60099
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
Saint Anthony Regional Hospital
Carroll, Iowa 51401
United States
UI Health Care Mission Cancer and Blood – West Des Moines Clinic
Clive, Iowa 50325
United States
Iowa Methodist Medical Center
Des Moines, Iowa 50309
United States
UI Health Care Mission Cancer and Blood – Des Moines Clinic
Des Moines, Iowa 50309
United States
Broadlawns Medical Center
Des Moines, Iowa 50314
United States
UI Health Care Mission Cancer and Blood – Laurel Clinic
Des Moines, Iowa 50314
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
UI Healthcare Mission Cancer and Blood – Fort Dodge
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
UI Healthcare Mission Cancer and Blood – Pella
Pella, Iowa 50219
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
The Iowa Clinic PC
West Des Moines, Iowa 50266
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Henry Ford Hospital
Detroit, Michigan 48202
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Minnesota Oncology – Burnsville
Burnsville, Minnesota 55337
United States
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Ridgeview Medical Center
Waconia, Minnesota 55387
United States
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Great Falls Clinic
Great Falls, Montana 59405
United States
Hi-Line Sletten Cancer Center
Havre, Montana 59501
United States
Benefis Helena Specialty Center
Helena, Montana 59601
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
AtlantiCare Health Park-Cape May Court House
Cape May Court House, New Jersey 08210
United States
AtlantiCare Surgery Center
Egg Harbor, New Jersey 08234
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Montefiore Medical Center-Einstein Campus
The Bronx, New York 10461
United States
Montefiore Medical Center – Moses Campus
The Bronx, New York 10467
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
MetroHealth Medical Center
Cleveland, Ohio 44109
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, Wisconsin 53151
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
Memorial Hospital of Laramie County
Cheyenne, Wyoming 82001
United States
Billings Clinic-Cody
Cody, Wyoming 82414
United States
Data Sources & Contacts
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