Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
Study Information
Alliance Study ID: A032302
NCT Study ID (ClinicalTrials.gov): NCT06931340
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Prostate Cancer
Alliance Study Chair: Deepak Kilari, MD
Status: RECRUITING
Study Description
This phase III trial compares the effect of adding docetaxel to hormonal therapy and apalutamide versus hormonal therapy and apalutamide alone in treating patients with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Hormone therapy for prostate cancer, also called androgen deprivation therapy (ADT), uses surgery or drugs to lower the levels of male sex hormones in a man’s body. This helps slow the growth of prostate cancer. Apalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of tumor cells. Giving docetaxel in addition to the usual treatment of hormonal therapy and apalutamide may work better in treating patients with metastatic prostate cancer than the usual treatment alone.
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Locations (195)
Banner University Medical Center – Tucson
Tucson, Arizona 85719
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
United States
Kaiser Permanente Dublin
Dublin, California 94568
United States
Kaiser Permanente-Fremont
Fremont, California 94538
United States
Kaiser Permanente Fresno Orchard Plaza
Fresno, California 93720
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
Kaiser Permanente- Modesto MOB II
Modesto, California 95356
United States
Kaiser Permanente-Modesto
Modesto, California 95356
United States
Kaiser Permanente-Oakland
Oakland, California 94611
United States
Eisenhower Medical Center
Rancho Mirage, California 92270
United States
Kaiser Permanente-Roseville
Roseville, California 95661
United States
Kaiser Permanente Downtown Commons
Sacramento, California 95814
United States
Kaiser Permanente-South Sacramento
Sacramento, California 95823
United States
UC San Diego Medical Center – Hillcrest
San Diego, California 92103
United States
Kaiser Permanente-San Francisco
San Francisco, California 94115
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
United States
Kaiser Permanente San Leandro
San Leandro, California 94577
United States
Kaiser San Rafael-Gallinas
San Rafael, California 94903
United States
Kaiser Permanente Medical Center – Santa Clara
Santa Clara, California 95051
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
United States
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
United States
Kaiser Permanente-Vallejo
Vallejo, California 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
United States
Kaiser Permanente-Franklin
Denver, Colorado 80205
United States
Saint Mary’s Hospital and Regional Medical Center
Grand Junction, Colorado 81501
United States
Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
United States
Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
United States
Bayhealth Hospital Kent Campus
Dover, Delaware 19901
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Bayhealth Hospital Sussex Campus
Milford, Delaware 19963
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia 20007
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia 20010
United States
Malcom Randall Veterans Administration Medical Center
Gainesville, Florida 32610
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
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Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
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Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Rush MD Anderson Cancer Center
Chicago, Illinois 60612
United States
University of Illinois
Chicago, Illinois 60612
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
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Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
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Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Carle BroMenn Medical Center
Normal, Illinois 61761
United States
Carle Cancer Institute Normal
Normal, Illinois 61761
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
HSHS Saint Elizabeth’s Hospital
O’Fallon, Illinois 62269
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Memorial Hospital East
Shiloh, Illinois 62269
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
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Illinois CancerCare – Washington
Washington, Illinois 61571
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Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
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McFarland Clinic – Boone
Boone, Iowa 50036
United States
Mercy Hospital
Cedar Rapids, Iowa 52403
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Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
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McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
HaysMed
Hays, Kansas 67601
United States
Lawrence Memorial Hospital
Lawrence, Kansas 66044
United States
The University of Kansas Cancer Center – Olathe
Olathe, Kansas 66061
United States
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
United States
Salina Regional Health Center
Salina, Kansas 67401
United States
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan 49829
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
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Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
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Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
University Health Truman Medical Center
Kansas City, Missouri 64108
United States
University of Kansas Cancer Center – Briarcliff
Kansas City, Missouri 64116
United States
University of Kansas Cancer Center – North
Kansas City, Missouri 64154
United States
University of Kansas Cancer Center – Lee’s Summit
Lee’s Summit, Missouri 64064
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
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Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
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Mercy Hospital Saint Louis
St Louis, Missouri 63141
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Community Hospital of Anaconda
Anaconda, Montana 59711
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Billings Clinic Cancer Center
Billings, Montana 59101
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Saint Vincent Frontier Cancer Center
Billings, Montana 59102
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Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
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Logan Health Medical Center
Kalispell, Montana 59901
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Community Medical Center
Missoula, Montana 59804
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
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Jefferson Cherry Hill Hospital
Cherry Hill, New Jersey 08002
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
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Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
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Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey 08080
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Guthrie Cortland Memorial Hospital
Cortland, New York 13045
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Mount Sinai Hospital
New York, New York 10029
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Stony Brook University Medical Center
Stony Brook, New York 11794
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Durham VA Medical Center
Durham, North Carolina 27705
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Duke University Medical Center
Durham, North Carolina 27710
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FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina 28374
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Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
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Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
ProMedica Flower Hospital
Sylvania, Ohio 43560
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Saint Vincent Hospital
Erie, Pennsylvania 16544
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Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
United States
Forbes Hospital
Monroeville, Pennsylvania 15146
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Allegheny Valley Hospital
Natrona Heights, Pennsylvania 15065
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
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Jefferson Torresdale Hospital
Philadelphia, Pennsylvania 19114
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Jefferson Methodist Hospital
Philadelphia, Pennsylvania 19148
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Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
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West Penn Hospital
Pittsburgh, Pennsylvania 15224
United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
United States
Saint Francis Hospital
Greenville, South Carolina 29601
United States
Saint Francis Cancer Center
Greenville, South Carolina 29607
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Self Regional Healthcare
Greenwood, South Carolina 29646
United States
Rapid City Regional Hospital
Rapid City, South Dakota 57701
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
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UT Southwestern Simmons Cancer Center – RedBird
Dallas, Texas 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
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Intermountain Medical Center
Murray, Utah 84107
United States
LDS Hospital
Salt Lake City, Utah 84143
United States
Saint George Regional Medical Center
St. George, Utah 84770
United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont 05602
United States
University of Vermont Medical Center
Burlington, Vermont 05401
United States
University of Vermont and State Agricultural College
Burlington, Vermont 05405
United States
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg, Virginia 22408
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
VCU Health Tappahannock Hospital
Tappahannock, Virginia 22560
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
Appleton, Wisconsin 54915
United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
Brookfield, Wisconsin 53045
United States
Ascension Calumet Hospital-Chilton
Chilton, Wisconsin 53014
United States
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
Franklin, Wisconsin 53132
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary’s
Green Bay, Wisconsin 54303
United States
William S Middleton VA Medical Center
Madison, Wisconsin 53705
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Ascension Columbia Saint Mary’s Hospital-Ozaukee Campus-Mequon
Mequon, Wisconsin 53097
United States
Ascension Columbia Saint Mary’s Hospital-Milwaukee Campus
Milwaukee, Wisconsin 53211
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, Wisconsin 53151
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
Oshkosh, Wisconsin 54904
United States
Ascension All Saints Hospital-Spring Street-Racine
Racine, Wisconsin 53405
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
United States
Sheboygan Physicians Group
Sheboygan, Wisconsin 53081
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
Wauwatosa, Wisconsin 53226
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
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