Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
Study Acronym: PREDICT
Study Information
Alliance Study ID: A032102
NCT Study ID (ClinicalTrials.gov): NCT06632977
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Prostate Cancer
Alliance Study Chair: Rana McKay, MD
Status: RECRUITING
Study Description
This phase II trial evaluates whether genetic testing in prostate cancer is helpful in deciding which study treatment patients are assigned. Patient cancer tissue samples are obtained from a previous surgery or biopsy procedure and tested for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) abnormalities or mutations in their cancer. Valemetostat tosylate is in a class of medications called EZH1/EZH2 inhibitors. It blocks proteins called EZH1 and EZH2, which may help slow or stop the spread of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Cabazitaxel injection is in a class of medications called microtubule inhibitors. It works by slowing or stopping the growth of tumor cells. Abiraterone acetate blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of tumor cells that need androgens to grow. It is a type of anti-androgen. Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of tumor cells. Lutetium Lu 177 vipivotide tetraxetan is in a class of medications called radiopharmaceuticals. It works by targeting and delivering radiation directly to tumor cells which damages and kills these cells. Assigning patients to targeted treatment based on genetic testing may help shrink or slow the cancer from growing
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
Locations (107)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
Banner University Medical Center – Tucson
Tucson, Arizona 85719
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
United States
Enloe Medical Center
Chico, California 95926
United States
UC San Diego Health System – Encinitas
Encinitas, California 92024
United States
UCI Health – Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
UC San Diego Medical Center – Hillcrest
San Diego, California 92103
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
United States
Memorial Hospital North
Colorado Springs, Colorado 80920
United States
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado 80631
United States
Medical Center of the Rockies
Loveland, Colorado 80538
United States
Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut 06904
United States
Beebe South Coastal Health Campus
Millville, Delaware 19967
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
Jupiter Medical Center
Jupiter, Florida 33458
United States
Tripler Army Medical Center
Honolulu, Hawaii 96859
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Memorial Hospital East
Shiloh, Illinois 62269
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa 52722
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States
University of Kansas Cancer Center
Kansas City, Kansas 66160
United States
The University of Kansas Cancer Center – Olathe
Olathe, Kansas 66061
United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas 66211
United States
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
Saint Elizabeth Healthcare Edgewood
Edgewood, Kentucky 41017
United States
Saint Elizabeth Healthcare Fort Thomas
Fort Thomas, Kentucky 41075
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Dana-Farber Cancer Institute at Foxborough
Foxborough, Massachusetts 02035
United States
Dana Farber-Merrimack Valley
Methuen, Massachusetts 01844
United States
Dana-Farber/Brigham and Women’s Cancer Center at Milford Regional
Milford, Massachusetts 01757
United States
Dana-Farber/Brigham and Women’s Cancer Center at South Shore
South Weymouth, Massachusetts 02190
United States
Baystate Medical Center
Springfield, Massachusetts 01199
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Essentia Health Saint Joseph’s Medical Center
Brainerd, Minnesota 56401
United States
Essentia Health Cancer Center
Duluth, Minnesota 55805
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
MU Health – University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri 65212
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Mount Sinai Hospital
New York, New York 10029
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
United States
MetroHealth Medical Center
Cleveland, Ohio 44109
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
United States
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina 29341
United States
Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
SMC Center for Hematology Oncology Union
Union, South Carolina 29379
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
Parkland Memorial Hospital
Dallas, Texas 75235
United States
UT Southwestern Simmons Cancer Center – RedBird
Dallas, Texas 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
United States
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
United States
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
United States
Bon Secours Richmond Community Hospital
Richmond, Virginia 23223
United States
Bon Secours Saint Mary’s Hospital
Richmond, Virginia 23226
United States
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, Virginia 23230
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Edwards Comprehensive Cancer Center
Huntington, West Virginia 25701
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
United States
Data Sources & Contacts
Full trial details
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