Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)
Study Information
Alliance Study ID: EAY191-A6
NCT Study ID (ClinicalTrials.gov): NCT05564403
Alliance Committee: Experimental Therapeutics
Disease or Cancer Type: Gastrointestinal Cancers – Pancreatic / Gastric / Esophageal / Liver / Biliary
Alliance Study Chair: Ardaman Shergill, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II ComboMATCH treatment trial compares the usual treatment of modified leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) chemotherapy to using binimetinib plus mFOLFOX6 chemotherapy to shrink tumors in patients with biliary tract cancers that have spread to other places in the body (advanced) and had progression of cancer after previous treatments (2nd line setting). Fluorouracil is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It works by killing tumor cells. Leucovorin may help the other drugs in the mFOLFOX6 chemotherapy regimen work better by making tumor cells more sensitive to the drugs. Binimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps to stop or slow the spread of tumor cells. Giving binimetinib in combination with mFOLFOX6 chemotherapy may be effective in shrinking or stabilizing advanced biliary tract cancers in the 2nd line setting.
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Locations (208)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
United States
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center – Jonesboro
Jonesboro, Arkansas 72401
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
Cedars-Sinai Medical Center
Los Angeles, California 90048
United States
Presbyterian Intercommunity Hospital
Whittier, California 90602
United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida 33176
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324
United States
Hawaii Cancer Care Inc – Waterfront Plaza
Honolulu, Hawaii 96813
United States
Queen’s Cancer Cenrer – POB I
Honolulu, Hawaii 96813
United States
Queen’s Medical Center
Honolulu, Hawaii 96813
United States
Queen’s Cancer Center – Kuakini
Honolulu, Hawaii 96817
United States
Hawaii Cancer Care – Westridge
‘Aiea, Hawaii 96701
United States
The Queen’s Medical Center – West Oahu
‘Ewa Beach, Hawaii 96706
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
United States
Northwestern University
Chicago, Illinois 60611
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
AMG Crystal Lake – Oncology
Crystal Lake, Illinois 60014
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Advocate Sherman Hospital
Elgin, Illinois 60123
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
AMG Libertyville – Oncology
Libertyville, Illinois 60048
United States
Condell Memorial Hospital
Libertyville, Illinois 60048
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
United States
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United States
Memorial Hospital East
Shiloh, Illinois 62269
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
UI Health Care Mission Cancer and Blood – Des Moines Clinic
Des Moines, Iowa 50309
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
United States
Walter Reed National Military Medical Center
Bethesda, Maryland 20889-5600
United States
National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
UPMC Western Maryland
Cumberland, Maryland 21502
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan 48109
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
University of Michigan – Brighton Center for Specialty Care
Brighton, Michigan 48116
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Corewell Health Dearborn Hospital
Dearborn, Michigan 48124
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan 48336
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan 48073
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan 48085
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Essentia Health – Deer River Clinic
Deer River, Minnesota 56636
United States
Essentia Health Cancer Center
Duluth, Minnesota 55805
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
United States
Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota 55072
United States
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705
United States
Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska 68123
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89183
United States
Renown Regional Medical Center
Reno, Nevada 89502
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Miami Valley Hospital
Dayton, Ohio 45409
United States
Premier Blood and Cancer Center
Dayton, Ohio 45409
United States
Dayton Physician LLC – Englewood
Dayton, Ohio 45415
United States
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
United States
Kettering Medical Center
Kettering, Ohio 45429
United States
Upper Valley Medical Center
Troy, Ohio 45373
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
United States
UPMC Altoona
Altoona, Pennsylvania 16601
United States
Lehigh Valley Hospital – Muhlenberg
Bethlehem, Pennsylvania 18017
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
United States
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
United States
UPMC Cancer Centers – Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
United States
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
United States
UPMC Hillman Cancer Center – Monroeville
Monroeville, Pennsylvania 15146
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania 15237
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
United States
UT MD Anderson – The Woodlands
Conroe, Texas 77384
United States
UT MD Anderson Cancer Center
Houston, Texas 77030
United States
UT MD Anderson – West Houston
Houston, Texas 77079
United States
UT MD Anderson – League City
League City, Texas 77573
United States
UT MD Anderson – Sugar Land
Sugar Land, Texas 77478
United States
University of Virginia Cancer Center
Charlottesville, Virginia 22908
United States
Inova Schar Cancer Institute
Fairfax, Virginia 22031
United States
Inova Fairfax Hospital
Falls Church, Virginia 22042
United States
Virginia Cancer Institute
Richmond, Virginia 23229
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
VCU Community Memorial Health Center
South Hill, Virginia 23970
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Valley Medical Center
Renton, Washington 98055
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
West Virginia University Healthcare
Morgantown, West Virginia 26506
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
United States
Duluth Clinic Ashland
Ashland, Wisconsin 54806
United States
ThedaCare Cancer Care – Berlin
Berlin, Wisconsin 54923
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Aurora Saint Luke’s South Shore
Cudahy, Wisconsin 53110
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
ThedaCare Regional Medical Center – Neenah
Neenah, Wisconsin 54956
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
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