A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy
Study Acronym: CASPAR
Study Information
Alliance Study ID: A031902
NCT Study ID (ClinicalTrials.gov): NCT04455750
Alliance Committee: Genitourinary Cancer
Disease or Cancer Type: Prostate Cancer
Alliance Study Chair: Arpit Rao, MD
Status: ACTIVE_NOT_RECRUITING
Study Description
This randomized, placebo-controlled phase III trial is evaluating the benefit of rucaparib and enzalutamide combination therapy versus enzalutamide alone for the treatment of men with prostate cancer that has spread to other places in the body (metastatic) and has become resistant to testosterone-deprivation therapy (castration-resistant). Enzalutamide helps fight prostate cancer by blocking the use of testosterone by the tumor cells for growth. Poly adenosine diphosphate (ADP)-ribose polymerase (PARP) inhibitors, such as rucaparib, fight prostate cancer by prevent tumor cells from repairing their DNA. Giving enzalutamide and rucaparib may make patients live longer or prevent their cancer from growing or spreading for a longer time, or both. It may also help doctors learn if a mutation in any of the homologous recombination DNA repair genes is helpful to decide which treatment is best for the patient.
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
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Houston, Texas 77030
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United States
VCU Community Memorial Health Center
South Hill, Virginia 23970
United States
Shenandoah Oncology PC
Winchester, Virginia 22601
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
United States
FHCC Overlake
Bellevue, Washington 98004
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
United States
Harrison Medical Center
Bremerton, Washington 98310
United States
Highline Medical Center-Main Campus
Burien, Washington 98166
United States
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Saint Elizabeth Hospital
Enumclaw, Washington 98022
United States
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Saint Francis Hospital
Federal Way, Washington 98003
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States
Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington 98034
United States
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
United States
Saint Clare Hospital
Lakewood, Washington 98499
United States
PeaceHealth Saint John Medical Center
Longview, Washington 98632
United States
Jefferson Healthcare
Port Townsend, Washington 98368
United States
Valley Medical Center
Renton, Washington 98055
United States
Pacific Gynecology Specialists
Seattle, Washington 98104
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
FHCC at Northwest Hospital
Seattle, Washington 98133
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
United States
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington 98405
United States
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Duluth Clinic Ashland
Ashland, Wisconsin 54806
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin 54601
United States
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Billings Clinic-Cody
Cody, Wyoming 82414
United States
Welch Cancer Center
Sheridan, Wyoming 82801
United States
Data Sources & Contacts
Full trial details
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