Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma
Study Information
Alliance Study ID: A091902
NCT Study ID (ClinicalTrials.gov): NCT04339738
Alliance Committee: Experimental Therapeutics
Disease or Cancer Type: Sarcoma & Soft Tissue / Bone Cancers
Alliance Study Chair: Juneko E Grilley-Olson
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II trial studies how well paclitaxel with and without nivolumab works in treating patients with soft tissue sarcoma that have not received taxane drugs, and how well nivolumab and cabozantinib work in treating taxane pretreated patients with soft tissue sarcoma. Nivolumab works through the body’s immune system to help the immune system act against tumor cells. Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. This trial is being done to see if the combination of nivolumab and paclitaxel or cabozantinib can shrink soft tissue sarcoma and possibly prevent it from coming back.
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Locations (171)
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
Mayo Clinic in Arizona
Scottsdale, Arizona 85259
United States
University of Arizona Cancer Center-Orange Grove Campus
Tucson, Arizona 85704
United States
Banner University Medical Center – Tucson
Tucson, Arizona 85719
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
United States
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
United States
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
United States
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
United States
Smilow Cancer Hospital Care Center – Guilford
Guilford, Connecticut 06437
United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States
Yale University
New Haven, Connecticut 06520
United States
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
United States
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477
United States
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
United States
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
United States
Smilow Cancer Hospital Care Center – Waterford
Waterford, Connecticut 06385
United States
Sibley Memorial Hospital
Washington D.C., District of Columbia 20016
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
United States
Moffitt Cancer Center-International Plaza
Tampa, Florida 33607
United States
Moffitt Cancer Center – McKinley Campus
Tampa, Florida 33612
United States
Moffitt Cancer Center
Tampa, Florida 33612
United States
Emory University Hospital Midtown
Atlanta, Georgia 30308
United States
Hawaii Cancer Care Inc – Waterfront Plaza
Honolulu, Hawaii 96813
United States
Island Urology
Honolulu, Hawaii 96813
United States
Queen’s Cancer Cenrer – POB I
Honolulu, Hawaii 96813
United States
Queen’s Medical Center
Honolulu, Hawaii 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii 96813
United States
University of Hawaii Cancer Center
Honolulu, Hawaii 96813
United States
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii 96817
United States
Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii 96817
United States
Kuakini Medical Center
Honolulu, Hawaii 96817
United States
Queen’s Cancer Center – Kuakini
Honolulu, Hawaii 96817
United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii 96826
United States
Straub Medical Center – Kahului Clinic
Kahului, Hawaii 96732
United States
Castle Medical Center
Kailua, Hawaii 96734
United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii 96766
United States
Hawaii Cancer Care – Westridge
‘Aiea, Hawaii 96701
United States
Pali Momi Medical Center
‘Aiea, Hawaii 96701
United States
Queen’s Cancer Center – Pearlridge
‘Aiea, Hawaii 96701
United States
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii 96701
United States
The Queen’s Medical Center – West Oahu
‘Ewa Beach, Hawaii 96706
United States
OSF Saint Anthony’s Health Center
Alton, Illinois 62002
United States
Rush-Copley Medical Center
Aurora, Illinois 60504
United States
Northwestern University
Chicago, Illinois 60611
United States
Rush MD Anderson Cancer Center
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
SSM Health Good Samaritan
Mount Vernon, Illinois 62864
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
The Carle Foundation Hospital
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
United States
Parkview Regional Medical Center
Fort Wayne, Indiana 46845
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
McFarland Clinic – Boone
Boone, Iowa 50036
United States
McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States
McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States
Central Care Cancer Center – Garden City
Garden City, Kansas 67846
United States
Central Care Cancer Center – Great Bend
Great Bend, Kansas 67530
United States
LSU Health Sciences Center at Shreveport
Shreveport, Louisiana 71103
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts 02114
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan 48109
United States
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States
Minnesota Oncology – Burnsville
Burnsville, Minnesota 55337
United States
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Unity Hospital
Fridley, Minnesota 55432
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Health Partners Inc
Minneapolis, Minnesota 55454
United States
Monticello Cancer Center
Monticello, Minnesota 55362
United States
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Ridgeview Medical Center
Waconia, Minnesota 55387
United States
Rice Memorial Hospital
Willmar, Minnesota 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States
Mercy Oncology and Hematology – Clayton-Clarkson
Ballwin, Missouri 63011
United States
Central Care Cancer Center – Bolivar
Bolivar, Missouri 65613
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Freeman Health System
Joplin, Missouri 64804
United States
Mercy Hospital Joplin
Joplin, Missouri 64804
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
United States
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
United States
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
CoxHealth South Hospital
Springfield, Missouri 65807
United States
Mercy Infusion Center – Chippewa
St Louis, Missouri 63109
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
Mercy Hospital Washington
Washington, Missouri 63090
United States
Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States
Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
United States
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina 28210
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
UPMC Hillman Cancer Center – Monroeville
Monroeville, Pennsylvania 15146
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
UPMC Susquehanna
Williamsport, Pennsylvania 17701
United States
Divine Providence Hospital
Williamsport, Pennsylvania 17754
United States
Smilow Cancer Hospital Care Center – Westerly
Westerly, Rhode Island 02891
United States
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina 29341
United States
Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
United States
North Grove Medical Park
Spartanburg, South Carolina 29303
United States
Spartanburg Medical Center
Spartanburg, South Carolina 29303
United States
Spartanburg Medical Center – Mary Black Campus
Spartanburg, South Carolina 29307
United States
SMC Center for Hematology Oncology Union
Union, South Carolina 29379
United States
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, Tennessee 37067
United States
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee 37204
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Fred Hutchinson Cancer Center
Seattle, Washington 98109
United States
University of Washington Medical Center – Montlake
Seattle, Washington 98195
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
FHP Health Center-Guam
Tamuning, 96913
Guam
Data Sources & Contacts
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