Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer
Study Information
Alliance Study ID: A021804
NCT Study ID (ClinicalTrials.gov): NCT04394858
Alliance Committee: Gastrointestinal Cancer
Disease or Cancer Type: Thyroid & Neuroendocrine / Endocrine Cancers
Alliance Study Chair: Jaydira Del Rivero
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II trial studies how well the addition of olaparib to the usual treatment, temozolomide, works in treating patients with neuroendocrine cancer (pheochromocytoma or paraganglioma) that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Poly (adenosine diphosphate [ADP]-ribose) polymerases (PARPs) are proteins that help repair deoxyribonucleic acid (DNA) mutations. PARP inhibitors, such as olaparib, can keep PARP from working, so tumor cells can’t repair themselves, and they may stop growing. Chemotherapy drugs, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving olaparib with temozolomide may shrink or stabilize the cancer in patients with pheochromocytoma or paraganglioma better than temozolomide alone.
Related Publications
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Locations (163)
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
United States
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
United States
Alaska Women’s Cancer Care
Anchorage, Alaska 99508
United States
Anchorage Oncology Centre
Anchorage, Alaska 99508
United States
Katmai Oncology Group
Anchorage, Alaska 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
United States
Holy Cross Hospital
Fort Lauderdale, Florida 33308
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Twin Falls
Twin Falls, Idaho 83301
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Centralia Oncology Clinic
Centralia, Illinois 62801
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
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Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
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Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
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Illinois CancerCare-Pekin
Pekin, Illinois 61554
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Illinois CancerCare-Peoria
Peoria, Illinois 61615
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Illinois CancerCare-Peru
Peru, Illinois 61354
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Illinois CancerCare-Princeton
Princeton, Illinois 61356
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Carle Cancer Center
Urbana, Illinois 61801
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Illinois CancerCare – Washington
Washington, Illinois 61571
United States
National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
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Dana-Farber Cancer Institute – Chestnut Hill
Newton, Massachusetts 02467
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
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Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
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Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
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Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
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Trinity Health Medical Center – Canton
Canton, Michigan 48188
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Caro Cancer Center
Caro, Michigan 48723
United States
Chelsea Hospital
Chelsea, Michigan 48118
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Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
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Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan 48236
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Henry Ford River District Hospital
East China Township, Michigan 48054
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
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Hurley Medical Center
Flint, Michigan 48503
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Henry Ford Saint John Hospital – Academic
Grosse Pointe Woods, Michigan 48236
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Henry Ford Saint John Hospital – Breast
Grosse Pointe Woods, Michigan 48236
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Henry Ford Saint John Hospital – Van Elslander
Grosse Pointe Woods, Michigan 48236
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University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Hope Cancer Clinic
Livonia, Michigan 48154
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Henry Ford Saint John Hospital – Macomb Medical
Macomb, Michigan 48044
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Henry Ford Warren Hospital – Breast Macomb
Macomb, Michigan 48044
United States
Saint Mary’s Oncology/Hematology Associates of Marlette
Marlette, Michigan 48453
United States
Hope Cancer Center
Pontiac, Michigan 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
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Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
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Henry Ford Rochester Hospital
Rochester Hills, Michigan 48309
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
United States
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan 48312
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
United States
Advanced Breast Care Center PLLC
Warren, Michigan 48088
United States
Henry Ford Health Warren Hospital
Warren, Michigan 48093
United States
Henry Ford Madison Heights Hospital – Breast
Warren, Michigan 48093
United States
Henry Ford Warren Hospital – GLCMS
Warren, Michigan 48093
United States
Macomb Hematology Oncology PC
Warren, Michigan 48093
United States
Saint Mary’s Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States
Minnesota Oncology – Burnsville
Burnsville, Minnesota 55337
United States
Cambridge Medical Center
Cambridge, Minnesota 55008
United States
Mercy Hospital
Coon Rapids, Minnesota 55433
United States
Fairview Southdale Hospital
Edina, Minnesota 55435
United States
Unity Hospital
Fridley, Minnesota 55432
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States
Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Health Partners Inc
Minneapolis, Minnesota 55454
United States
Monticello Cancer Center
Monticello, Minnesota 55362
United States
New Ulm Medical Center
New Ulm, Minnesota 56073
United States
Fairview Northland Medical Center
Princeton, Minnesota 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States
Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
United Hospital
Saint Paul, Minnesota 55102
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States
Lakeview Hospital
Stillwater, Minnesota 55082
United States
Ridgeview Medical Center
Waconia, Minnesota 55387
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Rice Memorial Hospital
Willmar, Minnesota 56201
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Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
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Fairview Lakes Medical Center
Wyoming, Minnesota 55092
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Saint Francis Medical Center
Cape Girardeau, Missouri 63703
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Saint Patrick Hospital – Community Hospital
Missoula, Montana 59802
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
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Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
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Albany Medical Center
Albany, New York 12208
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Memorial Sloan Kettering Commack
Commack, New York 11725
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Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
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Saint Charles Health System
Bend, Oregon 97701
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Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
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Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
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Bay Area Hospital
Coos Bay, Oregon 97420
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Providence Newberg Medical Center
Newberg, Oregon 97132
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Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
United States
Providence Portland Medical Center
Portland, Oregon 97213
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Providence Saint Vincent Medical Center
Portland, Oregon 97225
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Oregon Health and Science University
Portland, Oregon 97239
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Saint Charles Health System-Redmond
Redmond, Oregon 97756
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Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
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Lehigh Valley Hospital – Muhlenberg
Bethlehem, Pennsylvania 18017
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Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
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Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
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Dell Children’s Medical Center of Central Texas
Austin, Texas 78723
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Farmington Health Center
Farmington, Utah 84025
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
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University of Virginia Cancer Center
Charlottesville, Virginia 22908
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Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
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PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Providence Regional Cancer Partnership
Everett, Washington 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington 98632
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Pacific Gynecology Specialists
Seattle, Washington 98104
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Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
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Swedish Medical Center-First Hill
Seattle, Washington 98122
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PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
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Providence Regional Cancer System-Shelton
Shelton, Washington 98584
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PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
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Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
Data Sources & Contacts
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