Study Information

Alliance Study ID: A041701

NCT Study ID (ClinicalTrials.gov): NCT03701308

Alliance Committee: Leukemia

Disease or Cancer Type: Leukemia & Myelodysplastic Syndromes (MDS)

Alliance Study Chair: Geoffrey L Uy

Status: ACTIVE_NOT_RECRUITING


Study Description

This phase II/III trial studies how well daunorubicin and cytarabine with or without uproleselan works in treating older adult patients with acute myeloid leukemia receiving intensive induction chemotherapy. Drugs used in chemotherapy, such as daunorubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Uproleselan may prevent cancer from returning or getting worse. Giving daunorubicin and cytarabine with uproleselan may work better in treating patients with acute myeloid leukemia compared to daunorubicin and cytarabine alone.

Related Publications

For publications related to this and other clinical trials, visit the Alliance Publications Application.

Locations (188)

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
United States

Community Cancer Institute
Clovis, California 93611
United States

UC San Diego Moores Cancer Center
La Jolla, California 92093
United States

Loma Linda University Medical Center
Loma Linda, California 92354
United States

Cedars Sinai Medical Center
Los Angeles, California 90048
United States

Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
United States

Yale University
New Haven, Connecticut 06520
United States

Delaware Clinical and Laboratory Physicians PA
Newark, Delaware 19713
United States

Helen F Graham Cancer Center
Newark, Delaware 19713
United States

Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States

Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
United States

Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States

Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States

Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States

Walter Knox Memorial Hospital
Emmett, Idaho 83617
United States

Idaho Urologic Institute-Meridian
Meridian, Idaho 83642
United States

Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States

Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States

Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States

Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States

Illinois CancerCare-Canton
Canton, Illinois 61520
United States

Memorial Hospital of Carbondale
Carbondale, Illinois 62902
United States

SIH Cancer Institute
Carterville, Illinois 62918
United States

Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States

Centralia Oncology Clinic
Centralia, Illinois 62801
United States

Northwestern University
Chicago, Illinois 60611
United States

University of Illinois
Chicago, Illinois 60612
United States

University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States

Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States

Decatur Memorial Hospital
Decatur, Illinois 62526
United States

Crossroads Cancer Center
Effingham, Illinois 62401
United States

Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States

NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
United States

Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States

Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
United States

NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
United States

NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
United States

Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States

Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States

Loyola University Medical Center
Maywood, Illinois 60153
United States

UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States

Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States

University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States

Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States

Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States

Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States

Methodist Medical Center of Illinois
Peoria, Illinois 61636
United States

Illinois CancerCare-Peru
Peru, Illinois 61354
United States

Valley Radiation Oncology
Peru, Illinois 61354
United States

Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States

Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States

Springfield Clinic
Springfield, Illinois 62702
United States

Springfield Memorial Hospital
Springfield, Illinois 62781
United States

Southwest Illinois Health Services LLP
Swansea, Illinois 62226
United States

Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
United States

Mary Greeley Medical Center
Ames, Iowa 50010
United States

McFarland Clinic – Ames
Ames, Iowa 50010
United States

McFarland Clinic – Boone
Boone, Iowa 50036
United States

McFarland Clinic – Trinity Cancer Center
Fort Dodge, Iowa 50501
United States

University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
United States

McFarland Clinic – Jefferson
Jefferson, Iowa 50129
United States

McFarland Clinic – Marshalltown
Marshalltown, Iowa 50158
United States

Siouxland Regional Cancer Center
Sioux City, Iowa 51101
United States

University of Kansas Cancer Center
Kansas City, Kansas 66160
United States

Lawrence Memorial Hospital
Lawrence, Kansas 66044
United States

Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
United States

Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
United States

Cancer Center of Kansas – Wichita
Wichita, Kansas 67214
United States

Wesley Medical Center
Wichita, Kansas 67214
United States

University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States

Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
United States

Eastern Maine Medical Center
Bangor, Maine 04401
United States

Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
United States

Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States

Hickman Cancer Center
Adrian, Michigan 49221
United States

Henry Ford Hospital
Detroit, Michigan 48202
United States

Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States

Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
United States

Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States

West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States

Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
United States

Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan 48162
United States

Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
United States

Cancer and Hematology Centers of Western Michigan – Norton Shores
Norton Shores, Michigan 49444
United States

Corewell Health Reed City Hospital
Reed City, Michigan 49677
United States

Corewell Health Lakeland Hospitals – Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States

Munson Medical Center
Traverse City, Michigan 49684
United States

University of Michigan Health – West
Wyoming, Michigan 49519
United States

Fairview Ridges Hospital
Burnsville, Minnesota 55337
United States

Mercy Hospital
Coon Rapids, Minnesota 55433
United States

Essentia Health Cancer Center
Duluth, Minnesota 55805
United States

Fairview Southdale Hospital
Edina, Minnesota 55435
United States

Unity Hospital
Fridley, Minnesota 55432
United States

Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
United States

Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
United States

Saint John’s Hospital – Healtheast
Maplewood, Minnesota 55109
United States

Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
United States

Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States

Health Partners Inc
Minneapolis, Minnesota 55454
United States

Monticello Cancer Center
Monticello, Minnesota 55362
United States

New Ulm Medical Center
New Ulm, Minnesota 56073
United States

North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States

Mayo Clinic in Rochester
Rochester, Minnesota 55905
United States

Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States

Park Nicollet Clinic – Saint Louis Park
Saint Louis Park, Minnesota 55416
United States

Regions Hospital
Saint Paul, Minnesota 55101
United States

United Hospital
Saint Paul, Minnesota 55102
United States

Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
United States

Lakeview Hospital
Stillwater, Minnesota 55082
United States

Ridgeview Medical Center
Waconia, Minnesota 55387
United States

Rice Memorial Hospital
Willmar, Minnesota 56201
United States

Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
United States

Fairview Lakes Medical Center
Wyoming, Minnesota 55092
United States

Parkland Health Center-Bonne Terre
Bonne Terre, Missouri 63628
United States

Mercy Cancer Center – Cape Girardeau
Cape Girardeau, Missouri 63703
United States

Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States

Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States

Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States

Parkland Health Center – Farmington
Farmington, Missouri 63640
United States

MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri 65109
United States

Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States

Washington University School of Medicine
St Louis, Missouri 63110
United States

Siteman Cancer Center-South County
St Louis, Missouri 63129
United States

Missouri Baptist Medical Center
St Louis, Missouri 63131
United States

Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States

Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States

BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States

Community Hospital of Anaconda
Anaconda, Montana 59711
United States

Billings Clinic Cancer Center
Billings, Montana 59101
United States

Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States

Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States

Great Falls Clinic
Great Falls, Montana 59405
United States

Saint Peter’s Community Hospital
Helena, Montana 59601
United States

Logan Health Medical Center
Kalispell, Montana 59901
United States

Saint Patrick Hospital – Community Hospital
Missoula, Montana 59802
United States

Community Medical Center
Missoula, Montana 59804
United States

Nebraska Methodist Hospital
Omaha, Nebraska 68114
United States

OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States

OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
United States

Comprehensive Cancer Centers of Nevada – Central Valley
Las Vegas, Nevada 89169
United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
United States

Morristown Medical Center
Morristown, New Jersey 07960
United States

Overlook Hospital
Summit, New Jersey 07902
United States

Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States

North Shore University Hospital
Manhasset, New York 11030
United States

Long Island Jewish Medical Center
New Hyde Park, New York 11040
United States

Mount Sinai Hospital
New York, New York 10029
United States

University of Rochester
Rochester, New York 14642
United States

UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States

Duke University Medical Center
Durham, North Carolina 27710
United States

East Carolina University
Greenville, North Carolina 27834
United States

Wake Forest Baptist Health – Wilkes Medical Center
Wilkesboro, North Carolina 28659
United States

Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
United States

Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States

Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States

Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States

Case Western Reserve University
Cleveland, Ohio 44106
United States

MetroHealth Medical Center
Cleveland, Ohio 44109
United States

Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States

Mercy Health – Perrysburg Hospital
Perrysburg, Ohio 43551
United States

Mercy Health – Saint Anne Hospital
Toledo, Ohio 43623
United States

Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
United States

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States

Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon 97814
United States

Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States

Providence Portland Medical Center
Portland, Oregon 97213
United States

Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States

Geisinger Medical Center
Danville, Pennsylvania 17822
United States

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States

Rhode Island Hospital
Providence, Rhode Island 02903
United States

Medical University of South Carolina
Charleston, South Carolina 29425
United States

Saint Francis Hospital
Greenville, South Carolina 29601
United States

Saint Francis Cancer Center
Greenville, South Carolina 29607
United States

Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States

Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States

Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States

Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States

Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
United States

Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States

Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States

Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States

Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States

Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States

Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States

Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States

Billings Clinic-Cody
Cody, Wyoming 82414
United States

Welch Cancer Center
Sheridan, Wyoming 82801
United States

Data Sources & Contacts

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