Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
Study Information
Alliance Study ID: EAY191-A3
NCT Study ID (ClinicalTrials.gov): NCT05554367
Alliance Committee: Experimental Therapeutics
Disease or Cancer Type: Solid Tumors
Alliance Study Chair: Geoffrey I Shapiro
Status: ACTIVE_NOT_RECRUITING
Study Description
This phase II ComboMATCH treatment trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers. Palbociclib and binimetinib are both in a class of medications called kinase inhibitors. They work by blocking the action of abnormal proteins that signals cancer cells to multiply. This trial may help researchers understand if giving the combination of palbociclib and binimetinib can help improve the amount of time before the cancer grows in patients with patients with low grade serous ovarian cancer who have certain changes in the tumor DNA. This trial may also help researchers understand if giving the combination of palbociclib and binimetinib can help improve outcomes among patients with low grade serous ovarian cancer who have previously received a MEK inhibitor. For patients with other tumors, with the exception of lung cancer, colon cancer, melanoma and low grade serous ovarian cancers, this trial may help researchers understand if giving the combination of palbociclib and binimetinib can improve the clinical outcome of survival without progression in patients who have certain changes in their tumor’s DNA.
Related Publications
For publications related to this and other clinical trials, visit the Alliance Publications Application.
Locations (266)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
United States
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
United States
Providence Alaska Medical Center
Anchorage, Alaska 99508
United States
UC San Diego Health System – Encinitas
Encinitas, California 92024
United States
UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
VA Palo Alto Health Care System
Palo Alto, California 94304
United States
UC San Diego Medical Center – Hillcrest
San Diego, California 92103
United States
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
United States
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado 80631
United States
Medical Center of the Rockies
Loveland, Colorado 80538
United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United States
UF Health Cancer Institute – Gainesville
Gainesville, Florida 32610
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida 33176
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Kootenai Health – Coeur d’Alene
Coeur d’Alene, Idaho 83814
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Kootenai Clinic Cancer Services – Post Falls
Post Falls, Idaho 83854
United States
Kootenai Clinic Cancer Services – Sandpoint
Sandpoint, Idaho 83864
United States
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Northwestern University
Chicago, Illinois 60611
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United States
AMG Crystal Lake – Oncology
Crystal Lake, Illinois 60014
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Cancer Care Specialists of Illinois – Decatur
Decatur, Illinois 62526
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Advocate Sherman Hospital
Elgin, Illinois 60123
United States
Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
AMG Libertyville – Oncology
Libertyville, Illinois 60048
United States
Condell Memorial Hospital
Libertyville, Illinois 60048
United States
Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
Cancer Care Center of O’Fallon
O’Fallon, Illinois 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
United States
Advocate Outpatient Center – Oak Lawn
Oak Lawn, Illinois 60453
United States
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Advocate High Tech Medical Park
Palos Heights, Illinois 60463
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United States
Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Mercyhealth Cancer Institute – Rockford
Rockford, Illinois 61114
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
Illinois CancerCare – Washington
Washington, Illinois 61571
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
Mercy Hospital
Cedar Rapids, Iowa 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
United States
UI Health Care Mission Cancer and Blood – Des Moines Clinic
Des Moines, Iowa 50309
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States
Harold Alfond Center for Cancer Care
Augusta, Maine 04330
United States
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine 04074
United States
MaineHealth Cancer Care and IV Therapy – South Portland
South Portland, Maine 04106
United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
United States
Walter Reed National Military Medical Center
Bethesda, Maryland 20889-5600
United States
National Institutes of Health Clinical Center
Bethesda, Maryland 20892
United States
UPMC Western Maryland
Cumberland, Maryland 21502
United States
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Bronson Battle Creek
Battle Creek, Michigan 49017
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Corewell Health Dearborn Hospital
Dearborn, Michigan 48124
United States
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan 49829
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan 48336
United States
Cancer Hematology Centers – Flint
Flint, Michigan 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
Corewell Health Grand Rapids Hospitals – Butterworth Hospital
Grand Rapids, Michigan 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
United States
Corewell Health Lakeland Hospitals – Niles Hospital
Niles, Michigan 49120
United States
Cancer and Hematology Centers of Western Michigan – Norton Shores
Norton Shores, Michigan 49444
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
Corewell Health Reed City Hospital
Reed City, Michigan 49677
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan 48073
United States
Corewell Health Lakeland Hospitals – Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
United States
Corewell Health Lakeland Hospitals – Saint Joseph Hospital
Saint Joseph, Michigan 49085
United States
Munson Medical Center
Traverse City, Michigan 49684
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan 48085
United States
University of Michigan Health – West
Wyoming, Michigan 49519
United States
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Essentia Health – Deer River Clinic
Deer River, Minnesota 56636
United States
Essentia Health Cancer Center
Duluth, Minnesota 55805
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
Essentia Health Sandstone
Sandstone, Minnesota 55072
United States
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri 63376
United States
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Siteman Cancer Center-South County
St Louis, Missouri 63129
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Siteman Cancer Center at Christian Hospital
St Louis, Missouri 63136
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Community Hospital of Anaconda
Anaconda, Montana 59711
United States
Billings Clinic Cancer Center
Billings, Montana 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
United States
Logan Health Medical Center
Kalispell, Montana 59901
United States
Community Medical Center
Missoula, Montana 59804
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89183
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Mount Sinai Hospital
New York, New York 10029
United States
Upstate Cancer Center at Oswego
Oswego, New York 13126
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
Upstate Cancer Center at Verona
Verona, New York 13478
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Miami Valley Hospital South
Centerville, Ohio 45459
United States
Good Samaritan Hospital – Cincinnati
Cincinnati, Ohio 45220
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
United States
Riverside Methodist Hospital
Columbus, Ohio 43214
United States
Grant Medical Center
Columbus, Ohio 43215
United States
Doctors Hospital
Columbus, Ohio 43228
United States
Miami Valley Hospital
Dayton, Ohio 45409
United States
Premier Blood and Cancer Center
Dayton, Ohio 45409
United States
Dayton Physician LLC – Englewood
Dayton, Ohio 45415
United States
Miami Valley Hospital North
Dayton, Ohio 45415
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
United States
Grady Memorial Hospital
Delaware, Ohio 43015
United States
Columbus Oncology and Hematology Associates
Dublin, Ohio 43016
United States
Dublin Methodist Hospital
Dublin, Ohio 43016
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
United States
Kettering Medical Center
Kettering, Ohio 45429
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
United States
OhioHealth Marion General Hospital
Marion, Ohio 43302
United States
Upper Valley Medical Center
Troy, Ohio 45373
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Providence Newberg Medical Center
Newberg, Oregon 97132
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
United States
Providence Portland Medical Center
Portland, Oregon 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United States
UPMC Altoona
Altoona, Pennsylvania 16601
United States
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
United States
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
United States
UPMC Cancer Centers – Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
United States
Riddle Memorial Hospital
Media, Pennsylvania 19063
United States
UPMC Hillman Cancer Center – Monroeville
Monroeville, Pennsylvania 15146
United States
Paoli Memorial Hospital
Paoli, Pennsylvania 19301
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
United States
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania 15237
United States
Lankenau Medical Center
Wynnewood, Pennsylvania 19096
United States
Women and Infants Hospital
Providence, Rhode Island 02905
United States
Prisma Health Cancer Institute – Spartanburg
Boiling Springs, South Carolina 29316
United States
Prisma Health Cancer Institute – Easley
Easley, South Carolina 29640
United States
Prisma Health Cancer Institute – Butternut
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Faris
Greenville, South Carolina 29605
United States
Prisma Health Cancer Institute – Eastside
Greenville, South Carolina 29615
United States
Prisma Health Cancer Institute – Greer
Greer, South Carolina 29650
United States
Prisma Health Cancer Institute – Seneca
Seneca, South Carolina 29672
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Sanford USD Medical Center – Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
United States
Hendrick Medical Center
Abilene, Texas 79601
United States
Houston Methodist Hospital
Houston, Texas 77030
United States
UT MD Anderson Cancer Center
Houston, Texas 77030
United States
Methodist Willowbrook Hospital
Houston, Texas 77070
United States
Houston Methodist West Hospital
Houston, Texas 77094
United States
Houston Methodist Saint John Hospital
Nassau Bay, Texas 77058
United States
Houston Methodist Sugar Land Hospital
Sugar Land, Texas 77479
United States
Houston Methodist The Woodlands Hospital
The Woodlands, Texas 77385
United States
University of Virginia Cancer Center
Charlottesville, Virginia 22908
United States
Inova Schar Cancer Institute
Fairfax, Virginia 22031
United States
Inova Fairfax Hospital
Falls Church, Virginia 22042
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
United States
Swedish Medical Center-First Hill
Seattle, Washington 98122
United States
West Virginia University Healthcare
Morgantown, West Virginia 26506
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
United States
Duluth Clinic Ashland
Ashland, Wisconsin 54806
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
United States
Aurora Saint Luke’s South Shore
Cudahy, Wisconsin 53110
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary’s
Green Bay, Wisconsin 54303
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
United States
Mercyhealth Hospital and Cancer Center – Janesville
Janesville, Wisconsin 53548
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
University of Wisconsin Carbone Cancer Center – Eastpark Medical Center
Madison, Wisconsin 53718
United States
University of Wisconsin Carbone Cancer Center – University Hospital
Madison, Wisconsin 53792
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
United States
Aurora Saint Luke’s Medical Center
Milwaukee, Wisconsin 53215
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
United States
Vince Lombardi Cancer Clinic – Oshkosh
Oshkosh, Wisconsin 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
United States
Aurora Medical Center in Summit
Summit, Wisconsin 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Centro Comprensivo de Cancer de UPR
San Juan, 00927
Puerto Rico
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