Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative
Study Information
Alliance Study ID: A082002
NCT Study ID (ClinicalTrials.gov): NCT04929041
Alliance Committee: Respiratory Cancer
Disease or Cancer Type: Lung Cancer & Mesothelioma
Alliance Study Chair: Christine M Bestvina
Status: SUSPENDED
Study Description
This phase II/III trial compares the addition of radiation therapy to the usual treatment (immunotherapy with or without chemotherapy) versus (vs.) usual treatment alone in treating patients with non-small cell lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic) whose tumor is also negative for a molecular marker called PD-L1. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The addition of radiation therapy to usual treatment may stop the cancer from growing and increase the life of patients with advanced non-small cell lung cancer who are PD-L1 negative.
Related Publications
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Locations (170)
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
United States
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United States
City of Hope at Irvine Lennar
Irvine, California 92618
United States
City of Hope Antelope Valley
Lancaster, California 93534
United States
Fremont – Rideout Cancer Center
Marysville, California 95901
United States
Memorial Medical Center
Modesto, California 95355
United States
Providence Queen of The Valley
Napa, California 94558
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
United States
City of Hope South Pasadena
South Pasadena, California 91030
United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
United States
City of Hope Upland
Upland, California 91786
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
United States
Memorial Hospital North
Colorado Springs, Colorado 80920
United States
Poudre Valley Hospital
Fort Collins, Colorado 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
United States
UCHealth Greeley Hospital
Greeley, Colorado 80631
United States
Medical Center of the Rockies
Loveland, Colorado 80538
United States
Beebe South Coastal Health Campus
Millville, Delaware 19967
United States
Helen F Graham Cancer Center
Newark, Delaware 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
United States
Beebe Health Campus
Rehoboth Beach, Delaware 19971
United States
MedStar Washington Hospital Center
Washington D.C., District of Columbia 20010
United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United States
Morton Plant Hospital
Clearwater, Florida 33756
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida 33176
United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324
United States
Saint Joseph’s Hospital/Children’s Hospital-Tampa
Tampa, Florida 33607
United States
Winter Haven Hospital
Winter Haven, Florida 33881
United States
CTCA at Southeastern Regional Medical Center
Newnan, Georgia 30265
United States
Lewis Cancer and Research Pavilion at Saint Joseph’s/Candler
Savannah, Georgia 31405
United States
Saint Luke’s Cancer Institute – Boise
Boise, Idaho 83712
United States
Saint Luke’s Cancer Institute – Fruitland
Fruitland, Idaho 83619
United States
Saint Luke’s Cancer Institute – Meridian
Meridian, Idaho 83642
United States
Saint Luke’s Cancer Institute – Nampa
Nampa, Idaho 83687
United States
Saint Luke’s Cancer Institute – Twin Falls
Twin Falls, Idaho 83301
United States
Northwestern University
Chicago, Illinois 60611
United States
University of Illinois
Chicago, Illinois 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
United States
Carle at The Riverfront
Danville, Illinois 61832
United States
Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
United States
Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Crossroads Cancer Center
Effingham, Illinois 62401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
United States
Ingalls Memorial Hospital
Harvey, Illinois 60426
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
United States
HSHS Saint Elizabeth’s Hospital
O’Fallon, Illinois 62269
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
United States
UW Health Carbone Cancer Center Rockford
Rockford, Illinois 61114
United States
Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Springfield Clinic
Springfield, Illinois 62702
United States
Springfield Memorial Hospital
Springfield, Illinois 62781
United States
Carle Cancer Center
Urbana, Illinois 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
United States
UChicago Medicine Northwest Indiana
Crown Point, Indiana 46307
United States
Mary Greeley Medical Center
Ames, Iowa 50010
United States
McFarland Clinic – Ames
Ames, Iowa 50010
United States
UI Health Care Mission Cancer and Blood – Ankeny Clinic
Ankeny, Iowa 50023
United States
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
United States
UI Health Care Mission Cancer and Blood – West Des Moines Clinic
Clive, Iowa 50325
United States
Greater Regional Medical Center
Creston, Iowa 50801
United States
Iowa Methodist Medical Center
Des Moines, Iowa 50309
United States
UI Health Care Mission Cancer and Blood – Des Moines Clinic
Des Moines, Iowa 50309
United States
Mercy Medical Center – Des Moines
Des Moines, Iowa 50314
United States
UI Health Care Mission Cancer and Blood – Laurel Clinic
Des Moines, Iowa 50314
United States
UI Health Care Mission Cancer and Blood – Waukee Clinic
Waukee, Iowa 50263
United States
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
United States
The Iowa Clinic PC
West Des Moines, Iowa 50266
United States
CommonSpirit Saint Joseph Medical Center – East Lexington
Lexington, Kentucky 40509
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
United States
MaineHealth Cancer Care Center of York County
Sanford, Maine 04073
United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine 04074
United States
MaineHealth Cancer Care and IV Therapy – South Portland
South Portland, Maine 04106
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
United States
Trinity Health IHA Medical Group Hematology Oncology – Brighton
Brighton, Michigan 48114
United States
Trinity Health Medical Center – Brighton
Brighton, Michigan 48114
United States
Trinity Health IHA Medical Group Hematology Oncology – Canton
Canton, Michigan 48188
United States
Trinity Health Medical Center – Canton
Canton, Michigan 48188
United States
Chelsea Hospital
Chelsea, Michigan 48118
United States
Trinity Health IHA Medical Group Hematology Oncology – Chelsea Hospital
Chelsea, Michigan 48118
United States
Genesys Hurley Cancer Institute
Flint, Michigan 48503
United States
Hurley Medical Center
Flint, Michigan 48503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United States
University of Michigan Health – Sparrow Lansing
Lansing, Michigan 48912
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
United States
Saint Mary’s Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
United States
Miller-Dwan Hospital
Duluth, Minnesota 55805
United States
Hennepin County Medical Center
Minneapolis, Minnesota 55415
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
United States
Regions Hospital
Saint Paul, Minnesota 55101
United States
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Parkland Health Center – Farmington
Farmington, Missouri 63640
United States
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri 65401
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
United States
Mercy Hospital Springfield
Springfield, Missouri 65804
United States
Mercy Hospital South
St Louis, Missouri 63128
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
Mercy Hospital Saint Louis
St Louis, Missouri 63141
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
United States
Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
United States
Mount Sinai Chelsea
New York, New York 10011
United States
Mount Sinai West
New York, New York 10019
United States
Mount Sinai Hospital
New York, New York 10029
United States
Manhattan Eye Ear and Throat Hospital
New York, New York 10065
United States
Lenox Hill Hospital
New York, New York 10075
United States
Upstate Cancer Center at Oswego
Oswego, New York 13126
United States
Upstate Cancer Center Radiation Oncology at Oswego
Oswego, New York 13126
United States
State University of New York Upstate Medical University
Syracuse, New York 13210
United States
Upstate Cancer Center at Hill Radiation Oncology
Syracuse, New York 13210
United States
SUNY Upstate Medical Center-Community Campus
Syracuse, New York 13215
United States
Upstate Cancer Center at Verona
Verona, New York 13478
United States
Duke University Medical Center
Durham, North Carolina 27710
United States
Duke Cancer Center Raleigh
Raleigh, North Carolina 27609
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
United States
Summa Health System – Akron Campus
Akron, Ohio 44304
United States
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
United States
Geisinger Medical Center
Danville, Pennsylvania 17822
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
United States
Penn State Health Saint Joseph Medical Center
Reading, Pennsylvania 19605
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
United States
Medical University of South Carolina
Charleston, South Carolina 29425
United States
The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United States
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
United States
VCU Health Tappahannock Hospital
Tappahannock, Virginia 22560
United States
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684
United States
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
United States
West Virginia University Charleston Division
Charleston, West Virginia 25304
United States
Northwest Wisconsin Cancer Center
Ashland, Wisconsin 54806
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin 54601
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
United States
Marshfield Medical Center – Minocqua
Minocqua, Wisconsin 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
United States
Marshfield Medical Center – Weston
Weston, Wisconsin 54476
United States
Data Sources & Contacts
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